Findings

What do systematic reviews say?

1,835 questions · 1,886 findings · 74 reviews · Skin

Sort:Best matchNewestHighest certainty Download CSV

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Intervention not reported

Dupilumab (5 RCTs; 1997 participants) · patients with moderate to severe eczema

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1997 participants
High

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Total studies: 17 RCTsTotal participants: 3972 · patients with moderate to severe eczema

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
17 studies · 3972 participants
GRADE not reported

Intervention not reported

QAW039 (1 RCT; 76 participants) · patients with moderate to severe eczema

The intervention probably leads to lower QAW039 (1 RCT; 76 participants) (moderate certainty).

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
RR 0.09 [0.01, 0.76]
1 study · 39 participants
Moderate

Intervention not reported

Dupilumab (9 RCTs; 1663 participants) · patients with moderate to severe eczema

The intervention may leads to lower dupilumab (9 RCTs; 1663 participants) (low certainty).

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
RR 0.37 [0.23, 0.59]
9 studies · 1663 participants
Low

Intervention not reported

Timapiprant (1 RCT; 70 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in timapiprant (1 RCT; 70 participants) (low certainty).

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
RR 0.34 [0.07, 1.62]
1 study · 70 participants
Low

Topical antibiotics with steroids vs topical steroid

Global outcome (good or excellent improvement in symptoms or signs, or both) · people with eczema

Topical steroid plus topical antibiotic showed no clear difference in global outcome (good or excellent improvement in symptoms or signs,… compared with topical steroid (low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 1.1 [1, 1.21]
3 studies · 224 participants
Low

Oral antibiotics vs placebo

Withdrawals due to adverse events · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 199 participants
Very low

Oral antibiotics vs placebo

Minor adverse events not leading to withdrawal of treatment · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Very low

Oral antibiotics vs placebo

Microbiology Emergence of resistant organisms · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 98 participants
Very low

Oral antibiotics vs placebo

Global change in composite ratings scale EASI ranges from 0 to 72 with higher values indicating greater severity. · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Moderate

Oral antibiotics vs placebo

No of participants in whom S. aureus was isolated · people with atopic dermatitis

Oral antibiotic showed no clear difference in no of participants in whom S. aureus was isolated compared with placebo (low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 0.76 [0.46, 1.26]
3 studies · 144 participants
Low

Bleach bath vs placebo or bath emollient

Global outcome (good or excellent improvement in symptoms or signs, or both) · people with atopic dermatitis

Bleach bath showed no clear difference in global outcome (good or excellent improvement in symptoms or signs,… compared with placebo or bath emollient (low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 0.78 [0.37, 1.63]
1 study · 36 participants
Low

Bleach bath vs placebo or bath emollient

Change from baseline in quality of life CDLQI ranges from 0 to 30 with higher values indicating more impaired quality of life. · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Moderate

Bleach bath vs placebo or bath emollient

Withdrawals due to adverse events · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 42 participants
Very low

Bleach bath vs placebo or bath emollient

Minor adverse events not leading to withdrawal of treatment · people with atopic dermatitis

Bleach bath showed no clear difference in minor adverse events not requiring withdrawal from treatment compared with placebo or bath emollient (low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 1 [0.35, 2.87]
1 study · 36 participants
Low

Bleach bath vs placebo or bath emollient

Microbiology Emergence of resistant organisms · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Very low

Topical antibiotics with steroids vs topical steroid

Change from baseline in quality of life IDQoL ranges from 0 to 30 with higher values indicating more impaired quality of life · people with eczema

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 42 participants
Moderate

Bleach bath vs placebo or bath emollient

Global change in composite ratings scale EASI ranges from 0 to 72 with higher values indicating greater severity. · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 54 participants
Very low

Bleach bath vs placebo or bath emollient

No of participants in whom S. aureus was isolated · people with atopic dermatitis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found