Sildenafil vs IV nitroglycerin
- Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes onlyno estimate extracted1 study · 23 participantsLow
Sildenafil citrate showed no clear difference in fetal mortality compared with placebo or no therapy (moderate certainty).
Sildenafil citrate showed no clear difference in neonatal mortality compared with placebo or no therapy (moderate certainty).
Tadalafil showed no clear difference in all‐cause mortality compared with placebo or no therapy (low certainty).
Tadalafil showed no clear difference in fetal mortality compared with placebo or no therapy (low certainty).
Tadalafil showed no clear difference in neonatal mortality compared with placebo or no therapy (low certainty).
The review found no eligible studies for this question.
Dexamethasone showed no clear difference in neurodevelopmental disability at compared with betamethasone – child outcomes (moderate certainty).
Dexamethasone showed no clear difference in visual impairment compared with betamethasone – child outcomes (low certainty).
Dexamethasone showed no clear difference in hearing impairment compared with betamethasone – child outcomes (moderate certainty).
Dexamethasone showed no clear difference in developmental delay –motor (mild, moderate or severe) compared with betamethasone – child outcomes (moderate certainty).
Dexamethasone showed no clear difference in intellectual impairment: developmental delay – cognitive or language… compared with betamethasone – child outcomes (moderate certainty).
Dexamethasone showed no clear difference in cerebral palsy compared with betamethasone – child outcomes (low certainty).
It is very uncertain whether dexamethasone: oral changes any known death after randomisation (fetal, neonatal, child, child… compared with intramuscular – fetal/neonatal outcomes (very low certainty).
It is very uncertain whether dexamethasone: oral changes respiratory distress syndrome compared with intramuscular – fetal/neonatal outcomes (very low certainty).
It is very uncertain whether dexamethasone: oral changes intraventricular haemorrhage compared with intramuscular – fetal/neonatal outcomes (very low certainty).