Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,078 questions · 1,098 findings · 33 reviews · Skin

No studies found 396 · 36.1%GRADE not reported 89 · 8.1%Very low 181 · 16.5%Low 183 · 16.7%Moderate 196 · 17.9%High 53 · 4.8%

Itraconazole (200 mg for 6 to 8 weeks) vs placebo

Adverse effects Mild abdominal pain and nausea Adverse effects Mild abnormal liver function · patients with Old World cutaneous leishmaniasis

It is very uncertain whether itraconazole (200 mg for 6 to 8 weeks) changes adverse effects Mild abdominal pain and nausea Adverse effects Mild… compared with placebo (very low certainty).

1 finding from 1 review

Itraconazole (200 mg for 6 to 8 weeks) vs placebo

Microbiological or histopathological cure of skin lesions · patients with Old World cutaneous leishmaniasis

It is very uncertain whether itraconazole (200 mg for 6 to 8 weeks) changes microbiological or histopathological cure of skin lesions compared with placebo (very low certainty).

1 finding from 1 review

Paromomycin ointment vs vehicle

Proportion of participants with complete cure · patients with Old World cutaneous leishmaniasis

It is very uncertain whether paromomycin ointment changes percentage of participants with complete cure compared with vehicle (very low certainty).

1 finding from 1 review

Paromomycin ointment vs vehicle

Adverse effects Skin/local reactions · patients with Old World cutaneous leishmaniasis

It is very uncertain whether paromomycin ointment changes adverse effects Skin/local reactions compared with vehicle (very low certainty).

1 finding from 1 review

Minoxidil vs placebo

Proportion of participants with self‐rated clinically significant hair regrowth · women with FPHL

Minoxidil probably leads to higher the proportion of participants with self‐rated clinically… compared with placebo (moderate certainty).

1 finding from 1 review