Findings

What do systematic reviews say?

1,324 questions · 1,405 findings · 189 reviews

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No studies found 402 · 28.6%GRADE not reported 294 · 20.9%Very low 323 · 23%Low 232 · 16.5%Moderate 117 · 8.3%High 37 · 2.6%

Topical timolol vs placebo

Aesthetics · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral propranolol vs topical timolol

Clearance, as assessed by a clinician at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral propranolol vs topical timolol

A subjective measure of improvement, as assessed by the parent or child, at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral propranolol vs topical timolol

Other measures of resolution, as assessed by a clinician, at any · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in other measures of resolution, as assessed by a clinician, at any compared with topical timolol (low certainty).

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
RR 1.13 [0.64, 1.97]
1 study · 26 participants
Low

Oral propranolol vs topical timolol

Proportion of parents who consider their child still has a problem, at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral propranolol vs placebo

A subjective measure of improvement, as assessed by the parent or child, at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral propranolol vs topical timolol

Proportion of children who consider they still have a problem, at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral propranolol vs topical timolol

Aesthetics · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral propranolol vs placebo

Other measures of resolution, as assessed by a clinician, at any · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in other measures of resolution, as assessed by a clinician, at any compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
MD 45.9
1 study · 40 participants
Moderate

Oral propranolol vs placebo

Proportion of parents who consider their child still has a problem, at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral propranolol vs placebo

Proportion of children who consider they still have a problem, at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral propranolol vs placebo

Aesthetics · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical timolol vs placebo

Clearance, as assessed by a clinician at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical timolol vs placebo

A subjective measure of improvement, as assessed by the parent or child, at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for infantile haemangiomas of the skin 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pelvic floor muscle training before and after prolapse surgery vs no training

Objective failure at any site: at 12 to 24 months · women undergoing pelvic organ prolapse surgery

Pelvic floor muscle training before and after prolapse surgery showed no clear difference in objective failure at any site: at 12 to 24 months compared with no training (moderate certainty).

1 finding from 1 review

Perioperative interventions in pelvic organ prolapse surgery 2018 · Cochrane Headline outcomes only
OR 0.93 [0.56, 1.54]
2 studies · 327 participants
Moderate

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Oral mucositis (any severity) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.

4 findings from 1 review

Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
BMT/SCT after conditioning for haematological cancers
RR 0.96 [0.88, 1.05]
4 studies · 655 participants
GRADE not reported
Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
Children
Two studies of KGF versus placebo in children were unclear in reporting; no usable data could be presented
2 studies
GRADE not reported
Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
RT to head and neck with cisplatin/fluorouracil
RR 0.95 [0.90, 1.00]
2 studies · 374 participants
GRADE not reported

Show 1 more finding

Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
Chemotherapy alone for mixed cancers
RR 0.71 [0.60, 0.85]
2 studies · 215 participants
GRADE not reported

GM-CSF vs placebo or no treatment

Oral mucositis (any severity) · Adults with cancer receiving treatment

Granulocyte-macrophage colony-stimulating factor (GM-CSF) showed no clear difference in oral mucositis (any severity) compared with placebo or no treatment; GRADE not reported.

2 findings from 1 review

Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
BMT/SCT after conditioning for haematological cancers
RR 0.91 [0.80, 1.04]
1 study · 90 participants
GRADE not reported
Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
RT to head and neck
RR 1.01 [0.82, 1.23]
1 study · 29 participants
GRADE not reported

Granulocyte-colony stimulating factor (G-CSF; pegfilgrastim, single dose) vs Granulocyte-colony stimulating factor (G-CSF; filgrastim, multiple doses)

Oral mucositis (any severity) · Children receiving bone marrow/stem cell transplantation after conditioning therapy for mixed cancers

Granulocyte-colony stimulating factor (G-CSF; pegfilgrastim, single… showed no clear difference in oral mucositis (any severity) compared with granulocyte-colony stimulating factor (G-CSF; filgrastim, multiple…; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
Children
RR 1.02 [0.82, 1.27]
1 study · 61 participants
GRADE not reported

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs Chlorhexidine mouthwash

Oral mucositis (any severity) · Children with acute lymphoblastic leukaemia receiving chemotherapy alone

Keratinocyte growth factor (KGF), intravenous led to lower oral mucositis (any severity) compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
Children
RR 0.67 [0.54, 0.85]
1 study · 90 participants
GRADE not reported

G‐CSF vs placebo or no treatment

Oral mucositis (any severity) · Adults with cancer receiving treatment

Granulocyte-colony stimulating factor (G-CSF) led to lower oral mucositis (any severity) compared with placebo or no treatment; GRADE not reported.

2 findings from 1 review

Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
Chemotherapy alone for lung cancer
RR 0.59 [0.40, 0.87]
1 study · 195 participants
GRADE not reported
Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
RT to head and neck
RR 1.02 [0.86, 1.22]
2 studies · 54 participants
GRADE not reported