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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,280 questions in 114 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 37.5%Ungraded 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings: ECM vs ECT CFA: change in FFE (g/day) · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 2 studies · 41 participants | Low |
Summary of findings: ECM vs ECT Adverse events · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs ECT Pulmonary exacerbations · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs ECMM Change in weight · children with cystic fibrosis and proven pancreatic insufficiency Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs ECMM Change in height · children with cystic fibrosis and proven pancreatic insufficiency Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs ECMM Change in BMI · children with cystic fibrosis and proven pancreatic insufficiency Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs ECMM Frequency of bowel symptoms · children with cystic fibrosis and proven pancreatic insufficiency Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 54 participants | Very low |
Summary of findings: ECM vs ECMM CFA: change in FFE (g/day) · children with cystic fibrosis and proven pancreatic insufficiency Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 22 participants | Very low |
Summary of findings: ECM vs NECT plus cimetidine Change in height · adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs ECMM Adverse events · children with cystic fibrosis and proven pancreatic insufficiency Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs ECMM Pulmonary exacerbations · children with cystic fibrosis and proven pancreatic insufficiency Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM (Creon®) vs a different ECM Change in weight (kg) · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | MD 0 | 1 study · 83 participants | Moderate |
Summary of findings: ECM (Creon®) vs a different ECM Change in height · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM (Creon®) vs a different ECM Change in BMI · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM (Creon®) vs a different ECM Frequency of bowel symptoms: proportion of days with abdominal pain · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | MD 0 | 1 study · 83 participants | Low |
Summary of findings: ECM (Creon®) vs a different ECM CFA: CFA (%) · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | MD 1.35 | 2 studies · 110 participants | Moderate |
Summary of findings: ECM (Creon®) vs a different ECM Adverse events · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 83 participants | Low |
Summary of findings: ECM (Creon®) vs a different ECM Pulmonary exacerbations · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs TPE Change in weight (kg) · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 17 participants | Very low |
Summary of findings: ECM vs NECT plus cimetidine Change in BMI · adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs TPE Change in height · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs TPE Change in BMI · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs TPE Frequency of bowel symptoms · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs TPE CFA: change in FFE (g/day) · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 17 participants | Very low |
Summary of findings: ECM vs TPE Adverse events · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs TPE Pulmonary exacerbations · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs other enteric‐coated preparations Change in weight (kg) · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 2 studies · 56 participants | Very low |
Summary of findings: ECM vs other enteric‐coated preparations Change in height · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 45 participants | Very low |
Summary of findings: ECM vs other enteric‐coated preparations Change in BMI · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs other enteric‐coated preparations Frequency of bowel symptoms: stool frequency · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 2 studies · 56 participants | Very low |
Summary of findings: ECM vs NECT plus cimetidine Frequency in bowel symptoms: abdominal pain (% of days affected) · adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 12 participants | Very low |
Summary of findings: ECM vs other enteric‐coated preparations CFA: fat absorption · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 2 studies · 56 participants | Very low |
Summary of findings: ECM vs other enteric‐coated preparations Adverse events · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs other enteric‐coated preparations Pulmonary exacerbations · children with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: low‐dose vs high‐dose PERT Change in weight (kg) · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 17 participants | Very low |
Summary of findings: low‐dose vs high‐dose PERT Change in height · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: low‐dose vs high‐dose PERT Change in BMI · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: low‐dose vs high‐dose PERT Frequency of bowel symptoms: stool frequency · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 17 participants | Very low |
Summary of findings: low‐dose vs high‐dose PERT CFA: FFE (g/day) · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 17 participants | Very low |
Summary of findings: low‐dose vs high‐dose PERT Adverse events · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 2 studies · 146 participants | Very low |
Summary of findings: low‐dose vs high‐dose PERT Pulmonary exacerbations · children and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ECM vs NECT plus cimetidine CFA: change in FFE (g/day) · adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 12 participants | Low |
Summary of findings: liprotamase vs porcine PERT Change in weight (kg) · children aged 7 years or over and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 128 participants | Low |
Summary of findings: liprotamase vs porcine PERT Change in height · children aged 7 years or over and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: liprotamase vs porcine PERT Change in BMI · children aged 7 years or over and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: liprotamase vs porcine PERT Frequency of bowel symptoms: abdominal pain · children aged 7 years or over and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 128 participants | Low |
Summary of findings: liprotamase vs porcine PERT CFA: change from baseline (%) · children aged 7 years or over and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 128 participants | Low |
Summary of findings: liprotamase vs porcine PERT Adverse events · children aged 7 years or over and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 128 participants | Low |
Summary of findings: liprotamase vs porcine PERT Pulmonary exacerbations: number of exacerbations · children aged 7 years or over and adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | OR 0.56 [0.13, 2.45] | 1 study · 128 participants | Low |
Summary of findings: ECM vs NECT plus cimetidine Adverse events · adults with cystic fibrosis Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |