What do systematic reviews say?

Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA

It is very uncertain whether once‐daily ICS/LABA combined inhalers changes any COPD exacerbation that requires short‐burst oral corticosteroids… compared with once‐daily LAMA (very low certainty).

• Once‐daily long‐acting beta₂‐agonists/inhaled corticosteroids combined inhalers versus inhaled long‐acting muscarinic… 2018 · Cochrane Headline outcomes only
  OR 0.72 [0.35, 1.5]
  2 studies · 880 participants
  Very low

Summary of findings. Removable splintage vs cast

• Interventions for treating wrist fractures in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 65 participants
  Low

Summary of findings. Below‐elbow vs above‐elbow cast

The review found no eligible studies for this question.

• Interventions for treating wrist fractures in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

The review found no eligible studies for this question.

• Interventions for treating wrist fractures in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings. Home vs hospital‐clinic removal of casts

• Interventions for treating wrist fractures in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 233 participants
  Low

Summary of findings. Bandage vs cast

It is very uncertain whether summary of findings. Bandage changes physical function (short‐term): no problems or only 'limited… compared with cast (very low certainty).

• Interventions for treating wrist fractures in children 2018 · Cochrane Headline outcomes only
  RR 1.79 [1.18, 2.73]
  1 study · 53 participants
  Very low

Psychological therapy vs any comparator

• Psychological therapies for anxiety and depression in children and adolescents with long‐term physical conditions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  16 studies · 1121 participants
  Low

Psychological therapy vs any comparator

• Psychological therapies for anxiety and depression in children and adolescents with long‐term physical conditions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  13 studies · 578 participants
  Moderate

Psychological therapy vs any comparator

• Psychological therapies for anxiety and depression in children and adolescents with long‐term physical conditions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 464 participants
  Low

Psychological therapy vs any comparator

• Psychological therapies for anxiety and depression in children and adolescents with long‐term physical conditions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 483 participants
  Low

Psychological therapy vs any comparator

• Psychological therapies for anxiety and depression in children and adolescents with long‐term physical conditions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  14 studies · 823 participants
  Low

Cannabis oil (15% cannabidiol and 4% THC) vs placebo oil

• Cannabis for the treatment of Crohn's disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 39 participants
  Low

Cannabis cigarettes (115 mg THC) vs placebo cigarettes

The review found no eligible studies for this question.

• Cannabis for the treatment of Crohn's disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs sham

• Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 105 participants
  Moderate

Acupuncture as an addition to the routine primary care that trial participants were receiving from their physicians vs routine primary physician care alone

• Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 137 participants
  Low

Acupuncture as an addition to the routine primary care that trial participants were receiving from their physicians vs routine primary physician care alone

• Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 137 participants
  Low

Acupuncture vs advice plus exercise

The review found no eligible studies for this question.

• Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs advice plus exercise

The review found no eligible studies for this question.

• Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs sham

• Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 105 participants
  Moderate

Acupuncture as an addition to patient education vs education alone

• Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 25 participants
  GRADE not reported