Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

737 questions · 750 findings · 76 reviews

No studies found 182 · 24.3%GRADE not reported 95 · 12.7%Very low 229 · 30.5%Low 128 · 17.1%Moderate 76 · 10.1%High 40 · 5.3%

SiT for maintenance/relief vs higher‐dose ICS/LABA + SABA

Patients with serious adverse events · Studies recruited adults and adolescents aged 12 and older with chronic asthma

SiT for maintenance/relief showed no clear difference in patients with serious adverse events compared with higher‐dose ICS/LABA + SABA (moderate certainty).

1 finding from 1 review

SiT for maintenance/relief vs higher‐dose ICS/LABA + SABA

Patients with severe exacerbations (requiring hospitalisation or ER visit) · Studies recruited adults and adolescents aged 12 and older with chronic asthma

SiT for maintenance/relief leads to lower patients with severe exacerbations (requiring hospitalisation or ER… compared with higher‐dose ICS/LABA + SABA (high certainty).

1 finding from 1 review

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review · compare the 2 reviews

Interdental brushing plus toothbrushing vs Toothbrushing alone

Plaque · Adults, 16 years and older (dentate)

It is very uncertain whether interdental brushing plus toothbrushing changes plaque (Quigley & Hein plaque index, Turesky modification; scale 0… compared with toothbrushing alone (very low certainty).

1 finding from 1 review · compare the 2 reviews

Visual screening (oral visual inspection) by trained health workers vs No screening

Survival (proportion alive after diagnosis) · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…
1 finding from 1 review

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Periodontitis (clinical attachment loss) · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

1 finding from 1 review

Vertical ramus osteotomy (VRO) with osteosynthesis vs Vertical ramus osteotomy (VRO) without osteosynthesis

Changes in condyle position: fossa-condyle relations for anterior (1 year post-operative) · Adults (16 years of age or older) with an Angle Class III malocclusion (prominent lower front teeth); people with syndromes, clefts or…

Vertical ramus osteotomy (VRO) with osteosynthesis showed no clear difference in changes in condyle position: fossa-condyle relations for anterior (1… compared with vertical ramus osteotomy (VRO) without osteosynthesis; GRADE not reported.

1 finding from 1 review

Vertical ramus osteotomy (VRO) with osteosynthesis vs Vertical ramus osteotomy (VRO) without osteosynthesis

Changes in condyle position: fossa-condyle relations for posterior (1 year post-operative) · Adults (16 years of age or older) with an Angle Class III malocclusion (prominent lower front teeth); people with syndromes, clefts or…

Vertical ramus osteotomy (VRO) with osteosynthesis showed no clear difference in changes in condyle position: fossa-condyle relations for posterior… compared with vertical ramus osteotomy (VRO) without osteosynthesis; GRADE not reported.

1 finding from 1 review

Intraoral vertical ramus osteotomy (IVRO) vs Sagittal split ramus osteotomy (SSRO)

Stability of correction: vertical changes of pogonion (1 week to 1 year) · Adults (16 years of age or older) with an Angle Class III malocclusion (prominent lower front teeth); people with syndromes, clefts or…

Intraoral vertical ramus osteotomy (IVRO) showed no clear difference in stability of correction: vertical changes of pogonion (1 week to 1… compared with sagittal split ramus osteotomy (SSRO); GRADE not reported.

1 finding from 1 review

Any orthodontic and/or surgical treatment for Angle Class III malocclusion vs no intervention or another intervention

Correction of prominent lower front teeth / effectiveness of treatment (planned primary outcome) · Adults (16 years of age or older) with an Angle Class III malocclusion (prominent lower front teeth); people with syndromes, clefts or…

The review found no eligible studies for this question.

1 finding from 1 review
  • No included study measured the planned primary outcome. Discussion: 'The primary outcome proposed for this review was to evaluate the effectiveness of treatments for prognathism, but none of the studies conclusively…
    Studies not reported
    No studies found

Intervention not reported

Health outcomes · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Other outcomes · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Health service utilisation · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Cost · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Satisfaction, anxiety and confidence during pregnancy · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)
1 finding from 1 review

Intervention not reported

Pregnancy outcomes · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)
1 finding from 1 review

Intervention not reported

Health behaviour outcomes · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Smoking cessation · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)
1 finding from 1 review