Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,760 questions · 8,065 findings · 1,036 reviews

No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%

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Flowable resin composite vs Fluoride-releasing resin-based sealant

Retention of sealant (complete or partial retention) · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
1 finding from 1 review
  • Sealants for preventing dental caries in primary teeth 2022 · Cochrane All outcomes
    12 months
    Effect estimate not calculable. All sealants were completely or partially retained; 40 (1 RCT). Flowable composite: 39/40 completely retained (1 partially lost) at 6 months; resin-based: 33 completely and 7 partially…
    1 study · 40 participants
    Low

Lower‐dose methylnaltrexone vs higher dose

Laxation response: risk of spontaneous rescue‐free bowel movements in the short terma · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction

Methylnaltrexone lower dose showed no clear difference in laxation response: risk of spontaneous rescue‐free bowel… compared with higher dose (low certainty).

1 finding from 1 review

Lower‐dose methylnaltrexone vs higher dose

Laxation response: risk of spontaneous rescue‐free bowel movements in the medium termb · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction

It is very uncertain whether methylnaltrexone lower dose changes laxation response: risk of spontaneous rescue‐free bowel… compared with higher dose (very low certainty).

1 finding from 1 review