Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

974 questions · 987 findings · 137 reviews

No studies found 182 · 18.4%GRADE not reported 90 · 9.1%Very low 165 · 16.7%Low 312 · 31.6%Moderate 163 · 16.5%High 75 · 7.6%

Intervention not reported

Fatal injuries — not measured · Workers in positions with safety‐sensitive functions, other than commercial drivers

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Non‐fatal injuries — not measured · Workers in positions with safety‐sensitive functions, other than commercial drivers

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Non‐injury accidents — not measured · Workers in positions with safety‐sensitive functions, other than commercial drivers

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Absenteeism — not measured · Workers in positions with safety‐sensitive functions, other than commercial drivers

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events associated with RAT — not measured · Workers in positions with safety‐sensitive functions, other than commercial drivers

The review found no eligible studies for this question.

1 finding from 1 review

Silver diamine fluoride (SDF) vs Not applicable (single-arm safety outcome)

Serious adverse events · Children and older adults treated with SDF for carious lesions

No serious adverse events (e.g., allergic reactions or toxicity) were reported for SDF across the reviews (ungraded).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Not applicable (single-arm safety outcome)

Adverse events: black staining of arrested lesions · Children and older adults treated with SDF for carious lesions

Black staining of arrested lesions was the main adverse event of SDF (reported by seven reviews); it was generally acceptable to patients (ungraded).

1 finding from 1 review

Additional support vs usual care

Death of a baby (stillbirth or neonatal death) report of perinatal death · women at increased risk of low birthweight babies (maternal outcomes)

Additional support showed no clear difference in stillbirth/neonatal death compared with usual care during pregnancy (low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Complete remission · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in treatment response at 52 weeks: complete remission (primary outcome… compared with mycophenolate mofetil with pulse dexamethasone (moderate certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Partial remission ( · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in treatment response at 52 weeks: partial remission (primary outcome 3) compared with mycophenolate mofetil with pulse dexamethasone (moderate certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Sustainable remission between 52 and 78 weeks: complete or partial remission (primary outcome 1, 2, 3) · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in sustainable remission between 52 and 78 weeks: complete or partial… compared with mycophenolate mofetil with pulse dexamethasone (moderate certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

CKD or death: 50% decline in GFR by 78 weeks · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in CKD or death: 50% decline in GFR by 78 weeks compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse effects (weeks 0 to 26): serious infection requiring hospitalisation · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): serious infection requiring… compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse events: hypertension · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): hypertension compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review