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Evidence found and GRADE certainty

662 questions · 720 findings · 164 reviews

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No studies found 177 · 24.6%GRADE not reported 126 · 17.5%Very low 144 · 20%Low 139 · 19.3%Moderate 107 · 14.9%High 27 · 3.8%

Standard testing plus PET/CT scanning vs standard testing alone

Cancer‐related mortality at maximal · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in cancer‐related mortality3 compared with standard testing alone (moderate certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

VTE‐related morbidity5 · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in VTE‐related morbidity5 compared with standard testing alone (moderate certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

Stage at diagnosis (early-stage detection) · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in stage of cancer ‐ early compared with standard testing alone (low certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

Stage of cancer ‐ advanced · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in stage of cancer ‐ advanced compared with standard testing alone (low certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

Frequency of an underlying cancer diagnosis8 · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in frequency of an underlying cancer diagnosis8 compared with standard testing alone (moderate certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

All‐cause mortality1 · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in all‐cause mortality1 compared with standard testing alone (moderate certainty).

1 finding from 1 review

Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP) vs Bleaching alone (no remineralising agent)

Whitening (bleaching) efficacy · Demineralised / white-spot-lesion enamel (in vitro specimens)

Low-quality in vitro evidence indicates that adding fluoride or other remineralising agents does not impair the whitening/bleaching effect (ungraded).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Endometrial Polyps · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance probably leads to lower endometrial polyps compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Endometrial Hyperplasia · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance probably leads to lower endometrial hyperplasia compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Fibroids · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance showed no clear difference in fibroids compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Abnormal Vaginal Bleeding or Spotting · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance probably leads to higher abnormal vaginal bleeding or spotting compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Breast cancer recurrence · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance showed no clear difference in breast cancer recurrence compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Breast Cancer‐related Death · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance showed no clear difference in breast cancer‐related death compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review