What do systematic reviews say?

Altered WBRT fractionation schedules vs WBRT control: neurological function improvement

Altered WBRT fractionation schedules probably leads to higher neurological function improvement: lower‐dose WBRT vs control dose… compared with WBRT control: neurological function improvement (moderate certainty).

• Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
  OR 1.74 [1.06, 2.84]
  Studies not reported
  Moderate

Altered WBRT fractionation schedules vs WBRT control: neurological function improvement

Altered WBRT fractionation schedules showed no clear difference in neurological function improvement: higher‐dose WBRT vs control dose… compared with WBRT control: neurological function improvement (moderate certainty).

• Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
  OR 1.14 [0.92, 1.42]
  Studies not reported
  Moderate

WBRT with radiosensitisers (radiosen) vs WBRT

WBRT with radiosensitisers (radiosen) showed no clear difference in overall survivalNo. of participants: 2631(8 RCTs) compared with WBRT alone (moderate certainty).

• Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
  HR 1.05 [0.99, 1.12]
  Studies not reported
  Moderate

Hyperbaric oxygen vs air breathing

Hyperbaric oxygen showed no clear difference in mortality with urinary bladder cancer compared with air breathing (high certainty).

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  RR 0.97 [0.74, 1.27]
  4 studies · 330 participants
  High

Hyperbaric oxygen vs air breathing

The review found no eligible studies for this question.

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hyperbaric oxygen vs air breathing

The review found no eligible studies for this question.

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hyperbaric oxygen vs air breathing

Hyperbaric oxygen showed no clear difference in metastases with urinary bladder cancer compared with air breathing (moderate certainty).

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  RR 2 [0.58, 6.91]
  2 studies · 80 participants
  Moderate

Hyperbaric oxygen vs air breathing

The review found no eligible studies for this question.

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hyperbaric oxygen vs air breathing

Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  RR 2.35 [1.66, 3.33]
  7 studies · 779 participants
  High

Intervention not reported

• Antigen‐specific active immunotherapy for ovarian cancer 2018 · Cochrane Headline outcomes only
  no estimate extracted
  17 studies · 355 participants
  Very low

Intervention not reported

• Antigen‐specific active immunotherapy for ovarian cancer 2018 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 64 participants
  Very low

Intervention not reported

• Antigen‐specific active immunotherapy for ovarian cancer 2018 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1062 participants
  High

Intervention not reported

• Antigen‐specific active immunotherapy for ovarian cancer 2018 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 1882 participants
  High

Intervention not reported

• Antigen‐specific active immunotherapy for ovarian cancer 2018 · Cochrane Headline outcomes only
  no estimate extracted
  25 studies · 1521 participants
  Very low

Intervention not reported

• Antigen‐specific active immunotherapy for ovarian cancer 2018 · Cochrane Headline outcomes only
  no estimate extracted
  40 studies · 966 participants
  Very low

Summary of findings: Conformal RT vs conventional dose RT

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  GRADE not reported

Summary of findings: BT vs external beam radiotherapy (EBRT)

The review found no eligible studies for this question.

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Probiotics vs placebo or control

Summary of findings: Probiotics may leads to lower diarrhoea (grade 2+) compared with control (placebo or no intervention) (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 0.43 [0.22, 0.82]
  5 studies · 923 participants
  Low

Probiotics vs placebo or control

The review found no eligible studies for this question.

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Proteolytic enzymes vs placebo or control

The review found no eligible studies for this question.

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found