Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,783 questions · 10,022 findings · 882 reviews

No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Antibiotics vs placebo compared

Relapse · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze

Antibiotic therapy showed no clear difference in relapse (children who were 'cured' but developed symptoms within… compared with placebo compared to placebo (low certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Any adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy showed no clear difference in any adverse events compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Progression‐free survival · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy probably leads to lower progression‐free survival compared with placebo, best supportive care (BSC) or no treatment (moderate certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy showed no clear difference in serious adverse events compared with placebo, best supportive care (BSC) or no treatment (low certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Tumour response · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy may leads to higher tumour response rate compared with placebo, best supportive care (BSC) or no treatment (low certainty).

1 finding from 1 review