Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

57 questions · 60 findings · 5 reviews · Skin

No studies found 23 · 38.3%GRADE not reported 4 · 6.7%Very low 10 · 16.7%Low 2 · 3.3%Moderate 17 · 28.3%High 4 · 6.7%

Azithromycin vs placebo or vitamins

Minor participant‐reported adverse events not requiring withdrawal of the treatment: Mild abdominal pain. · pityriasis rosea

Azithromycin showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo or vitamins (moderate certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Acyclovir probably leads to lower proportion of participants with resolution of itch within 2 weeks,… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea

Acyclovir probably leads to higher the proportion of participants with good or excellent rash… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

Acyclovir showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants achieving 'clearance' by IGA · scalp psoriasis

Steroid probably leads to higher number of participants achieving 'clearance' by IGA compared with vitamin D (moderate certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants achieving 'response' by IGA · scalp psoriasis

Steroid leads to higher number of participants achieving 'response' by IGA compared with vitamin D (high certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants withdrawing due to adverse events (AE) · scalp psoriasis

Steroid probably leads to lower number of participants withdrawing due to adverse events (AE) compared with vitamin D (moderate certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants achieving 'response' by PGA · scalp psoriasis

Steroid probably leads to higher number of participants achieving 'response' by PGA compared with vitamin D (moderate certainty).

1 finding from 1 review