Findings

What do systematic reviews say?

80 questions · 84 findings · 9 reviews

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No studies found 19 · 22.6%GRADE not reported 3 · 3.6%Very low 12 · 14.3%Low 40 · 47.6%Moderate 10 · 11.9%High 0 · 0%

Oral misoprostol vs vaginal misoprostol

Nausea · women undergoing first trimester abortion

Oral misoprostol may leads to higher nausea compared with vaginal misoprostol (low certainty).

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.14 [1.03, 1.26]
2 studies · 1380 participants
Low
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.21 [0.92, 1.61]
2 studies · 216 participants
Low

Oral misoprostol vs vaginal misoprostol

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

The review found no eligible studies for this question.

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.25 [0.65, 2.39]
1 study · 100 participants
Low

Oral misoprostol vs vaginal misoprostol

Blood transfusion · women undergoing first trimester abortion

The review found no eligible studies for this question.

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral misoprostol vs vaginal dinoprostone

Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower uterine hyperstimulation with fetal heart rate changesÂ compared with vaginal dinoprostone (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.49 [0.4, 0.59]
11 studies · 9084 participants
Low

Oral misoprostol vs vaginal dinoprostone

Oxytocin augmentation · women in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes oxytocin augmentationÂ compared with vaginal dinoprostone (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.9 [0.75, 1.09]
12 studies · 9451 participants
Very low

Oral misoprostol vs vaginal dinoprostone

Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol probably leads to lower uterine hyperstimulation without fetal heart rate changesÂ compared with vaginal dinoprostone (moderate certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.83 [0.72, 0.97]
9 studies · 8171 participants
Moderate

Oral misoprostol vs vaginal dinoprostone

Apgar score less than 7 at 5 minutes · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in apgar score less than seven at five minutesÂ compared with vaginal dinoprostone (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.8 [0.52, 1.23]
12 studies · 9473 participants
Low

Oral misoprostol vs vaginal dinoprostone

Admission to neonatal intensive care unit · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in admission to neonatal intensive care unitÂ compared with vaginal dinoprostone (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.8 [0.6, 1.07]
11 studies · 9278 participants
Low

Oral misoprostol vs vaginal dinoprostone

Caesarean section · women in the third trimester for induction of labour.

Oral misoprostol probably leads to lower caesarean section compared with vaginal dinoprostone (moderate certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.84 [0.78, 0.9]
13 studies · 9676 participants
Moderate

Sublingual misoprostol vs vaginal misoprostol

Failure to achieve complete abortion · women undergoing first trimester abortion

Sublingual misoprostol showed no clear difference in failure to achieve complete abortion compared with vaginal misoprostol (moderate certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.68 [0.22, 2.11]
2 studies · 3229 participants
Moderate

Sublingual misoprostol vs vaginal misoprostol

Nausea · women undergoing first trimester abortion

Sublingual misoprostol showed no clear difference in nausea compared with vaginal misoprostol (moderate certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.11 [0.93, 1.33]
3 studies · 3543 participants
Moderate

Sublingual misoprostol vs vaginal misoprostol

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

Sublingual misoprostol showed no clear difference in women's dissatisfaction with the procedure compared with vaginal misoprostol (moderate certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.67 [0.8, 3.5]
2 studies · 3303 participants
Moderate

Sublingual misoprostol vs vaginal misoprostol

Blood transfusion · women undergoing first trimester abortion

The review found no eligible studies for this question.

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sublingual misoprostol vs vaginal misoprostol

Failure to achieve complete abortion · first trimester abortion

Sublingual misoprostol alone showed no clear difference in failure to achieve complete abortion compared with vaginal misoprostol alone (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.69 [0.37, 1.28]
5 studies · 2705 participants
Low

Sublingual misoprostol vs vaginal misoprostol

Nausea · first trimester abortion

Sublingual misoprostol alone showed no clear difference in nausea compared with vaginal misoprostol alone (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.61 [0.78, 3.33]
4 studies · 2505 participants
Low

Sublingual misoprostol vs vaginal misoprostol

Women's dissatisfaction with the procedure · first trimester abortion

Sublingual misoprostol alone may leads to lower women's dissatisfaction with the procedure compared with vaginal misoprostol alone (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.14 [0.07, 0.29]
1 study · 220 participants
Low

Sublingual misoprostol vs vaginal misoprostol

Blood transfusion · first trimester abortion

It is very uncertain whether sublingual misoprostol alone changes blood transfusion compared with vaginal misoprostol alone (very low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 5 [0.24, 102.96]
1 study · 220 participants
Very low

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Mortality due to bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes mortality due to bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
RR 6.21 [0.77, 49.98]
1 study · 116 participants
Very low

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Hysterectomy to control bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes hysterectomy to control bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
RR 4.14 [0.48, 35.93]
1 study · 116 participants
Very low

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found