Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

68 questions · 76 findings · 8 reviews · Headline outcomes only

No studies found 10 · 13.2%GRADE not reported 0 · 0%Very low 10 · 13.2%Low 38 · 50%Moderate 16 · 21.1%High 2 · 2.6%

Tacrolimus 0.1% vs pimecrolimus 1%

Physician's assessment of global response of improvement, clear or excellent ‐ 6 weeks · people with atopic dermatitis

Tacrolimus 0.1% probably leads to higher physician's assessment of global response of improvement, clear or… compared with pimecrolimus 1% (moderate certainty).

1 finding from 1 review

Tacrolimus 0.1% vs pimecrolimus 1%

Adverse effects ‐ 6 weeks · people with atopic dermatitis

It is very uncertain whether tacrolimus 0.1% changes adverse effects ‐ 6 weeks compared with pimecrolimus 1% (very low certainty).

1 finding from 1 review

Tacrolimus 0.03% vs pimecrolimus 1%

Physician's assessment of global response of improvement · people with atopic dermatitis

Tacrolimus 0.03% may leads to higher physician's assessment of global response of improvement compared with pimecrolimus 1% (low certainty).

1 finding from 1 review

Tacrolimus 0.03% vs pimecrolimus 1%

Adverse effects ‐ application site reaction · people with atopic dermatitis

Tacrolimus 0.03% showed no clear difference in adverse effects ‐ application site reaction compared with pimecrolimus 1% (low certainty).

1 finding from 1 review

Tacrolimus 0.1% vs mometasone furoate ointment

Primary: investigator‐rated good/excellent control of symptoms · people with moderate to severe chronic relapsing dyshidrotic eczema on hands

The review found no eligible studies for this question.

1 finding from 1 review

Tacrolimus 0.1% vs mometasone furoate ointment

Primary: participant‐rated good/excellent control of symptoms Not measured · people with moderate to severe chronic relapsing dyshidrotic eczema on hands

The review found no eligible studies for this question.

1 finding from 1 review

Tacrolimus 0.1% vs vehicle

Primary: investigator‐rated good/excellent control of symptoms · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

Topical calcineurin inhibitors: tacrolimus 0.1% ointment probably leads to higher primary: investigator‐rated good/excellent control of symptoms compared with vehicle (moderate certainty).

1 finding from 1 review