Findings

What do systematic reviews say?

108 questions · 108 findings · 7 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 42 · 38.9%GRADE not reported 1 · 0.9%Very low 41 · 38%Low 20 · 18.5%Moderate 4 · 3.7%High 0 · 0%

Recombinant human growth hormone vs placebo or no intervention

Measures of mineral metabolism: change in serum phosphate mmol/L · children with X‐linked hypophosphataemia

It is very uncertain whether summary of findings ‐ recombinant growth hormone changes measures of mineral metabolism: change in serum phosphate mmol/L compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Recombinant growth hormone therapy for X‐linked hypophosphatemia in children 2021 · Cochrane Headline outcomes only
MD 0.18 [0.08, 0.28]
2 studies · 20 participants
Very low

Recombinant human growth hormone vs placebo or no intervention

Alkaline phosphatase · children with X‐linked hypophosphataemia

1 finding from 1 review

Recombinant growth hormone therapy for X‐linked hypophosphatemia in children 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 20 participants
Low

Recombinant human growth hormone vs placebo or no intervention

Measures of renal function: change in TmP/GFR · children with X‐linked hypophosphataemia

It is very uncertain whether summary of findings ‐ recombinant growth hormone changes measures of renal function: change in TmP/GFR compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Recombinant growth hormone therapy for X‐linked hypophosphatemia in children 2021 · Cochrane Headline outcomes only
MD 0.01
2 studies · 20 participants
Very low

Recombinant human growth hormone vs placebo or no intervention

Body proportions: sitting height SDS · children with X‐linked hypophosphataemia

Summary of findings ‐ recombinant growth hormone showed no clear difference in body proportions: sitting height SDS compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Recombinant growth hormone therapy for X‐linked hypophosphatemia in children 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 15 participants
Moderate

Recombinant human growth hormone vs placebo or no intervention

Adverse effects · children with X‐linked hypophosphataemia

1 finding from 1 review

Recombinant growth hormone therapy for X‐linked hypophosphatemia in children 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 20 participants
Low

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Time taken from start of treatment until the resolution of DIOS · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Treatment failure rate · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Adherence · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Episodes of acute DIOS · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Adverse effects: abdominal mass · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Abdominal pain · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Mood or personal well‐being · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Coping strategies · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

QoL · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Physical health: pain intensity (VAS post‐treatment scores) · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Family adjustment · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control

Mood or personal well‐being: change in distress (according to General Severity Index) · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Very low

Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control

Coping strategies · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control

QoL · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control

Physical health: number of bags of blood required, mean factor usage scores · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 44 participants
Low