Findings

What do systematic reviews say?

48 questions · 49 findings · 5 reviews · Common Mental Disorders

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No studies found 2 · 4.1%GRADE not reported 3 · 6.1%Very low 15 · 30.6%Low 17 · 34.7%Moderate 9 · 18.4%High 3 · 6.1%

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Improvement in depression at 6‐12 weeks: HAM‐D score (continuous) · adults living with HIV and depression

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Improvement in depression at 6‐12 weeks: HAM‐D score (dichotomized) · adults living with HIV and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes improvement in depression at 6‐12 weeks: HAM‐D score (dichotomized) compared with tricyclic antidepressant (TCA) (very low certainty).

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
RR 0.89 [0.54, 1.46]
2 studies · 64 participants
Very low

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) · adults living with HIV and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) compared with tricyclic antidepressant (TCA) (very low certainty).

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
RR 1.24 [0.68, 2.24]
2 studies · 64 participants
Very low

Tricyclic antidepressants vs SSRI

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

TCAs showed no clear difference in failure to respond compared with SSRI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.08 [0.71, 1.66]
4 studies · 438 participants
Low

Tricyclic antidepressants vs SSRI

Leaving the study early · adults with panic disorder

TCAs showed no clear difference in total number of dropouts compared with SSRI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.98 [0.65, 1.48]
7 studies · 928 participants
Low

Tricyclic antidepressants vs SSRI

Failure to remit at endpoint · adults with panic disorder

TCAs showed no clear difference in failure to remit compared with SSRI (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.89 [0.63, 1.26]
5 studies · 475 participants
Moderate

Tricyclic antidepressants vs SSRI

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 243 participants
Very low

Tricyclic antidepressants vs SSRI

Withdrawals due to adverse events · adults with panic disorder

TCAs showed no clear difference in number of dropouts due to adverse effects compared with SSRI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.43 [0.82, 2.48]
5 studies · 476 participants
Low