Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

162 questions · 167 findings · 24 reviews · Musculoskeletal

No studies found 65 · 38.9%GRADE not reported 6 · 3.6%Very low 24 · 14.4%Low 55 · 32.9%Moderate 16 · 9.6%High 1 · 0.6%

Ultrasound‐guided injection vs non‐image‐guided injection

Participant‐assessed success 50% improvement on numerical rating 0 to 10 scale for pain) · Patients with shoulder pain

It is very uncertain whether ultrasound‐guided injection changes participant‐assessed success 50% improvement on numerical rating 0… compared with non‐image‐guided injection (very low certainty).

1 finding from 1 review

Intervention not reported

Participation restrictions 100 mm return to usual work activities VAS (higher score reflects better outcome) · people with non‐neurological conditions1
1 finding from 1 review

Intervention not reported

Participation restrictions · people with neurological conditions1

The review found no eligible studies for this question.

1 finding from 1 review

Celecoxib vs placebo

Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · patients with rheumatoid arthritis

Celecoxib probably leads to higher clinical improvement: American College of Rheumatology 20%… compared with placebo (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · patients with rheumatoid arthritis

Celecoxib showed no clear difference in clinical improvement: American College of Rheumatology 20%… compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Intervention not reported

ACR 50 American College of Rheumatology improvement criteria · patients with rheumatoid arthritis

The intervention probably leads to higher ACR 50 American College of Rheumatology improvement criteria (moderate certainty).

1 finding from 1 review

Intervention not reported

ACR50 American College of Rheumatology 50% improvement criteria · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention probably leads to higher ACR50 American College of Rheumatology 50% improvement criteria (moderate certainty).

1 finding from 1 review

Intervention not reported

Outcome: ACR50 ‐ American College of Rheumatology Improvement Criteria · participants with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

ACR50 American College of Rheumatology improvement criteria · participants with rheumatoid arthritis and with partial response to MTX

The intervention probably leads to higher ACR50 American College of Rheumatology improvement criteria (moderate certainty).

1 finding from 1 review

Uncemented fixation with and without hydroxyapatite vs cemented fixation

Arthroplasty instability ‐ inferred from roentgen stereophotogrammetric analysis (Available data analysis) · Patients with osteoarthritis and other non‐traumatic diseases

Uncemented fixation with and without hydroxyapatite probably leads to lower arthroplasty instability ‐ inferred from roentgen… compared with cemented fixation (moderate certainty).

1 finding from 1 review

Febuxostat 120 mg/day vs placebo

Serum uric acid <6.0 mg/dL at final visit · patients with chronic cout

Febuxostat 120 mg/day may leads to higher serum uric acid <6.0 mg/dL at final visit compared with placebo (low certainty).

1 finding from 1 review

Febuxostat 40 mg/day vs placebo

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 40 mg/day may leads to higher serum uric acid <6.0 mg/dL at final visit compared with placebo (low certainty).

1 finding from 1 review

Febuxostat 40 mg/day vs allopurinol

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 40 mg/day showed no clear difference in serum uric acid <6.0 mg/dL at final visit compared with allopurinol (moderate certainty).

1 finding from 1 review

Febuxostat 80 mg/day vs allopurinol

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 80 mg/day may leads to higher serum uric acid <6.0 mg/dL at final visit compared with allopurinol (low certainty).

1 finding from 1 review