Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

191 questions · 225 findings · 21 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 50 · 22.2%GRADE not reported 8 · 3.6%Very low 62 · 27.6%Low 55 · 24.4%Moderate 38 · 16.9%High 12 · 5.3%

Dexrazoxane vs no cardioprotective intervention or placebo

Heart failure · adults with cancer receiving anthracyclines

Dexrazoxane probably leads to lower clinical heart failure Available case analysis compared with no cardioprotective intervention or placebo (moderate certainty).

1 finding from 1 review

Dexrazoxane vs no cardioprotective intervention or placebo

Clinical heart failure and subclinical myocardial dysfunction combined Comparable definitions; see Characteristics of included studies for exact definitions. Available‐case analysis · adults with cancer receiving anthracyclines

Dexrazoxane probably leads to lower clinical heart failure and subclinical myocardial dysfunction… compared with no cardioprotective intervention or placebo (moderate certainty).

2 findings from 1 review

Dexrazoxane vs no cardioprotective intervention or placebo

Overall survival (Illustrative comparative risks reported as number of alive participants) · adults with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in overall survival (Illustrative comparative risks reported as number… compared with no cardioprotective intervention or placebo (moderate certainty).

1 finding from 1 review

Dexrazoxane vs no cardioprotective intervention or placebo

Progression‐free survival · adults with cancer receiving anthracyclines

Dexrazoxane may leads to lower progression‐free survival Defined as time from first date of… compared with no cardioprotective intervention or placebo (low certainty).

3 findings from 1 review

Dexrazoxane vs no cardioprotective intervention or placebo

Partial response (partial or complete response) · adults with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in tumour response rate Defined as number of complete or partial… compared with no cardioprotective intervention or placebo (moderate certainty).

1 finding from 1 review

Cediranib plus chemotherapy vs placebo plus chemotherapy

Specific adverse events: serious haemorrhage · women with persistent, recurrent, or metastatic cervical cancer

It is very uncertain whether cediranib plus chemotherapy changes specific adverse events: serious haemorrhage compared with placebo plus chemotherapy (very low certainty).

1 finding from 1 review

Cediranib plus chemotherapy vs placebo plus chemotherapy

Specific adverse events: serious thromboembolic events · women with persistent, recurrent, or metastatic cervical cancer

It is very uncertain whether cediranib plus chemotherapy changes specific adverse events: serious thromboembolic events compared with placebo plus chemotherapy (very low certainty).

1 finding from 1 review