Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

489 questions · 532 findings · 33 reviews · Headline outcomes only

No studies found 55 · 10.3%GRADE not reported 28 · 5.3%Very low 119 · 22.4%Low 167 · 31.4%Moderate 129 · 24.2%High 34 · 6.4%

Phamacotherapies that specifically target ammonia vs placebo or non‐absorbable disaccharides

Blood ammonia concentrations (units unspecified) · adults with cirrhosis and hepatic encephalopathy
3 findings from 1 review

Phamacotherapies that specifically target ammonia vs placebo or non‐absorbable disaccharides

Blood ammonia concentrations (µmol/L*week) · adults with cirrhosis and hepatic encephalopathy
2 findings from 1 review

Non‐platinum therapies vs platinum combination

Grade 3 or higher hematological toxicity for platinum therapies ‐ anemia · non‐small cell lung cancer in the elderly population

Non‐platinum therapies may leads to higher grade 3 or higher hematological toxicity for platinum therapies ‐… compared with platinum combination (low certainty).

1 finding from 1 review

Non‐platinum therapies vs platinum combination

Grade 3 or higher hematological toxicity for platinum therapies ‐ thrombocytopenia · non‐small cell lung cancer in the elderly population

Non‐platinum therapies may leads to higher grade 3 or higher hematological toxicity for platinum therapies ‐… compared with platinum combination (low certainty).

1 finding from 1 review

Non‐platinum therapies vs platinum combination

Grade 3 or higher Non‐Hematological Toxicity for Platinum‐based therapies ‐ Peripheral neuropathy · non‐small cell lung cancer in the elderly population

Non‐platinum therapies may leads to higher grade 3 or higher Non‐Hematological Toxicity for Platinum‐based… compared with platinum combination (low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Clinical non‐response at post‐treatment · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes clinical non‐response at post‐treatment compared with other psychological therapies (very low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Clinical non‐response at · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes clinical non‐response at compared with other psychological therapies (very low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Acceptability (number of participants lost to post‐treatment assessment) · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes treatment acceptability at post‐treatment Dropout rates compared with other psychological therapies (very low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Secondary outcome: acceptability of treatment · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes treatment acceptability at compared with other psychological therapies (very low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Clinical non‐remission at post‐treatment · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes non‐remission at post‐treatment compared with other psychological therapies (very low certainty).

1 finding from 1 review