Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

149 questions · 153 findings · 18 reviews

No studies found 22 · 14.4%GRADE not reported 30 · 19.6%Very low 29 · 19%Low 44 · 28.8%Moderate 27 · 17.6%High 1 · 0.7%

Antiplatelet drug vs control

Recurrent ischaemic or unknown stroke during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes recurrent ischaemic/unknown stroke during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Symptomatic intracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes symptomatic intracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Major extracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes major extracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Osmotic‐release oral system methylphenidate vs placebo

Proportion of individuals withdrawing from treatment · people with ADHD and epilepsy

Osmotic‐release oral system methylphenidate probably leads to higher proportion of people withdrawing from treatment compared with placebo (moderate certainty).

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract showed no clear difference in systemic fungal infection compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Death associated with fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract showed no clear difference in death associated with fungal infection compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Good compliance · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract led to higher good compliance compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review

Antifungal drugs not absorbed from GI tract vs placebo or no treatment

Death associated with fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs not absorbed from GI tract showed no clear difference in death associated with fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs not absorbed from GI tract vs placebo or no treatment

Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs not absorbed from GI tract showed no clear difference in systemic fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs partially absorbed from GI tract (miconazole, clotrimazole) vs placebo or no treatment

Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs partially absorbed from GI tract (miconazole,… showed no clear difference in systemic fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole,… showed no clear difference in systemic fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review