Findings

What do systematic reviews say?

47 questions · 50 findings · 2 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 13 · 26%Very low 16 · 32%Low 14 · 28%Moderate 7 · 14%High 0 · 0%

Neurodevelopmental disability · ventilated preterm infants with planned extubation

nHFV showed no clear difference in neurodevelopmental disability compared with nIPPV (low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 0.88 [0.35, 2.16]
1 study · 72 participants
Low

Death or chronic lung disease · preterm infants with respiratory distress for initial respiratory support

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants with respiratory distress for initial respiratory support

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Neurodevelopmental disability · preterm infants with respiratory distress for initial respiratory support

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Mortality before hospital discharge · newborn (term* and preterm) infants with respiratory distress for initial respiratory support

It is very uncertain whether nHFV changes mortality before hospital discharge compared with nCPAP used (very low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 1 [0.41, 2.41]
4 studies · 531 participants
Very low

Endotracheal intubation To discharge · newborn (term* and preterm) infants with respiratory distress for initial respiratory support

nHFV may leads to lower endotracheal intubation To discharge compared with nCPAP used (low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 0.52 [0.33, 0.82]
5 studies · 571 participants
Low

Chronic lung disease · newborn (term* and preterm) infants with respiratory distress for initial respiratory support

nHFV showed no clear difference in chronic lung disease compared with nCPAP used (low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 1.35 [0.8, 2.27]
4 studies · 481 participants
Low