Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

63 questions · 63 findings · 6 reviews

No studies found 17 · 27%GRADE not reported 0 · 0%Very low 14 · 22.2%Low 12 · 19%Moderate 15 · 23.8%High 5 · 7.9%

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Treatment adherence (defined as dose reduction) ( · neoadjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in treatment adherence (defined as dose reduction) ( compared with anthracyclines followed by taxane (moderate certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (binary outcome) All‐cause mortality for the duration of · patients with oesophageal cancer

Non‐surgical showed no clear difference in long‐term mortality (binary): definitive chemoradiotherapy versus… compared with surgical treatment of oesophageal cancer (primary outcomes) (low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (time‐to‐event outcome): chemoradiotherapy versus surgery All‐cause mortality for the duration of · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes long‐term mortality (time‐to‐event): definitive chemoradiotherapy… compared with surgical treatment of oesophageal cancer (primary outcomes) (very low certainty).

1 finding from 1 review

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Treatment adherence (defined as dose delay) ( · adjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in treatment adherence (defined as dose delay) ( compared with anthracyclines followed by taxane (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

pCR: hormone receptor‐positive · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in pCR: hormone receptor‐positive compared with non‐capecitabine‐containing regimens (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

pCR: hormone receptor‐negative · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in pCR: hormone receptor‐negative compared with non‐capecitabine‐containing regimens (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Disease-free survival · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in disease‐free survivalmedian compared with non‐capecitabine‐containing regimens (high certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Overall survivalmedian · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in overall survivalmedian compared with non‐capecitabine‐containing regimens (high certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Febrile neutropenia · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in febrile neutropenia compared with non‐capecitabine‐containing regimens (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Diarrhoea · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens probably leads to higher diarrhoea compared with non‐capecitabine‐containing regimens (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Hand‐foot syndrome · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens probably leads to higher hand‐foot syndrome compared with non‐capecitabine‐containing regimens (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Pathological complete response · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in pathological complete response (pCR): breast and axillary nodes compared with non‐capecitabine‐containing regimens (high certainty).

1 finding from 1 review

Physical activity vs usual care

Overall survival (time interval between enrolment in the study and death of the person from any cause) · adults with non‐advanced colorectal cancer treated surgically or with neoadjuvant or adjuvant therapy, or both

The review found no eligible studies for this question.

1 finding from 1 review