Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

47 questions · 52 findings · 5 reviews

No studies found 5 · 9.6%GRADE not reported 0 · 0%Very low 7 · 13.5%Low 26 · 50%Moderate 6 · 11.5%High 8 · 15.4%

Intervention not reported

Functional performance on activities of daily living: ADCS‐ADL19 54‐point scale · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    11 studies · 2687 participants
    High

Intervention not reported

Behaviour and Mood (NPI) · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    14 studies · 3674 participants
    High

Intervention not reported

Binary outcomes · Alzheimer's disease (AD), moderate‐to‐severe

The review found no eligible studies for this question.

1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Intervention not reported

All‐cause discontinuation · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    17 studies · 5087 participants
    High

Intervention not reported

Number suffering at least one adverse event · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    29 studies · 8033 participants
    High

Intervention not reported

Number suffering at least one serious adverse event · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    19 studies · 6482 participants
    High

Intervention not reported

Number suffering agitation as an adverse event · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    12 studies · 4395 participants
    Moderate