What do systematic reviews say?

Chloral hydrate oral (50 mg/kg) vs melatonin oral

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse events (any) compared with melatonin oral (low certainty).

• Chloral hydrate as a sedating agent for neurodiagnostic procedures in children 2021 · Cochrane Headline outcomes only
  RR 1 [0.25, 3.93]
  1 study · 348 participants
  Low

Myo‐inositol vs antioxidant (melatonin)

The review found no eligible studies for this question.

• Inositol for subfertile women with polycystic ovary syndrome 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Myo‐inositol vs antioxidant (melatonin)

The review found no eligible studies for this question.

• Inositol for subfertile women with polycystic ovary syndrome 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Myo‐inositol vs antioxidant (melatonin)

It is very uncertain whether myo‐inositol changes adverse event ‐ miscarriage compared with antioxidant (melatonin) (very low certainty).

• Inositol for subfertile women with polycystic ovary syndrome 2018 · Cochrane Headline outcomes only
  OR 0.7 [0.22, 2.24]
  1 study · 358 participants
  Very low

Myo‐inositol vs antioxidant (melatonin)

It is very uncertain whether myo‐inositol changes adverse event ‐ multiple pregnancy compared with antioxidant (melatonin) (very low certainty).

• Inositol for subfertile women with polycystic ovary syndrome 2018 · Cochrane Headline outcomes only
  OR 0.95 [0.57, 1.59]
  1 study · 358 participants
  Very low

Myo‐inositol vs antioxidant (melatonin)

It is very uncertain whether myo‐inositol changes clinical pregnancy compared with antioxidant (melatonin) (very low certainty).

• Inositol for subfertile women with polycystic ovary syndrome 2018 · Cochrane Headline outcomes only
  OR 0.83 [0.53, 1.28]
  1 study · 358 participants
  Very low

Intervention not reported

• Effects of opioid, hypnotic and sedating medications on sleep‐disordered breathing in adults with obstructive sleep… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intervention not reported

• Effects of opioid, hypnotic and sedating medications on sleep‐disordered breathing in adults with obstructive sleep… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intervention not reported

• Effects of opioid, hypnotic and sedating medications on sleep‐disordered breathing in adults with obstructive sleep… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intervention not reported

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  18 studies · 1264 participants
  Moderate

Intervention not reported

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 176 participants
  Low

Intervention not reported

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 35 participants
  Low

Intervention not reported

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 44 participants
  Very low

Intervention not reported

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 36 participants
  Low

Intervention not reported

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 524 participants
  Low

Intervention not reported

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 73 participants
  Low

Intervention not reported

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 36 participants
  Low

Intervention not reported

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 409 participants
  Moderate

Intervention not reported

The review found no eligible studies for this question.

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Melatonin for preoperative and postoperative anxiety in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 35 participants
  Low