Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

748 questions · 782 findings · 58 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 164 · 21%GRADE not reported 26 · 3.3%Very low 151 · 19.3%Low 222 · 28.4%Moderate 158 · 20.2%High 61 · 7.8%

Bevacizumab plus chemotherapy vs chemotherapy alone

Specific adverse events: serious thromboembolic events · women with persistent, recurrent, or metastatic cervical cancer

Bevacizumab plus chemotherapy probably leads to higher specific adverse events: serious thromboembolic events compared with chemotherapy (moderate certainty).

1 finding from 1 review

Bevacizumab plus chemotherapy vs chemotherapy alone

Adverse events: hypertension · women with persistent, recurrent, or metastatic cervical cancer

Bevacizumab plus chemotherapy probably leads to higher specific adverse events: hypertension compared with chemotherapy (moderate certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

All‐cause mortality · people with cancer who have febrile neutropenia

Pre‐emptive antifungal therapy showed no clear difference in all‐cause mortality compared with empirical antifungal therapy (low certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

Mortality ascribed to fungal infection · people with cancer who have febrile neutropenia

Pre‐emptive antifungal therapy showed no clear difference in mortality ascribed to fungal infection compared with empirical antifungal therapy (low certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

Proportion of antifungal agent use (other than prophylactic use) · people with cancer who have febrile neutropenia

It is very uncertain whether pre‐emptive antifungal therapy changes proportion of antifungal agent use (other than prophylactic use) compared with empirical antifungal therapy (very low certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

Duration of antifungal use (days) · people with cancer who have febrile neutropenia

It is very uncertain whether pre‐emptive antifungal therapy changes duration of antifungal use (days) compared with empirical antifungal therapy (very low certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

Invasive fungal infection detection · people with cancer who have febrile neutropenia

It is very uncertain whether pre‐emptive antifungal therapy changes invasive fungal infection detection compared with empirical antifungal therapy (very low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with radiotherapy vs Radiotherapy alone

Progression‐free survival (PSF) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with radiotherapy showed no clear difference in progression‐free survival Median compared with radiotherapy alone (low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with radiotherapy vs Radiotherapy alone

Death (all causes) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with radiotherapy showed no clear difference in overall survival Median compared with radiotherapy alone (low certainty).

1 finding from 1 review