Findings

What do systematic reviews say?

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

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No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Early (less than seven days following birth) higher vs lower sodium intake

Neurodevelopmental disability · preterm or low birth weight infants

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Early (less than seven days following birth) higher vs lower sodium intake

Hyponatraemia (< 130 mmol/L) · preterm or low birth weight infants

Early (less than seven days following birth) higher showed no clear difference in hyponatraemia (< 130 mmol/L) compared with lower sodium intake (low certainty).

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
RR 0.68 [0.4, 1.13]
3 studies · 83 participants
Low

Early (less than seven days following birth) higher vs lower sodium intake

Hypernatraemia (≥ 150 mmol/L) · preterm or low birth weight infants

Early (less than seven days following birth) higher showed no clear difference in hypernatraemia (≥ 150 mmol/L) compared with lower sodium intake (low certainty).

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
RR 1.62 [1, 2.65]
4 studies · 103 participants
Low

Early (less than seven days following birth) higher vs lower sodium intake

Postnatal growth failure · preterm or low birth weight infants

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Early (less than seven days following birth) higher vs lower sodium intake

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether early (less than seven days following birth) higher changes necrotising enterocolitis compared with lower sodium intake (very low certainty).

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
RR 4.6 [0.23, 90.84]
1 study · 46 participants
Very low

Early (less than seven days following birth) higher vs lower sodium intake

Chronic lung disease · preterm or low birth weight infants

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Low vs standard dose valganciclovir

All‐cause death · solid organ transplant recipients

Low showed no clear difference in all‐cause death compared with standard dose valganciclovir (low certainty).

1 finding from 1 review

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients 2024 · Cochrane Headline outcomes only
RR 0.2 [0.11, 4.11]
1 study · 196 participants
Low

Low vs standard dose valganciclovir

CMV infection · solid organ transplant recipients

Low showed no clear difference in CMV infection compared with standard dose valganciclovir (low certainty).

1 finding from 1 review

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients 2024 · Cochrane Headline outcomes only
RR 0.37 [0.11, 1.22]
2 studies · 256 participants
Low

Low vs standard dose valganciclovir

Acute rejection · solid organ transplant recipients

Low showed no clear difference in acute rejection compared with standard dose valganciclovir (low certainty).

1 finding from 1 review

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients 2024 · Cochrane Headline outcomes only
RR 0.33 [0.07, 1.61]
1 study · 196 participants
Low

Low vs standard dose valganciclovir

Graft loss · solid organ transplant recipients

Low showed no clear difference in graft loss compared with standard dose valganciclovir (low certainty).

1 finding from 1 review

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients 2024 · Cochrane Headline outcomes only
RR 1 [0.06, 15.76]
1 study · 196 participants
Low

Low vs standard dose valganciclovir

Opportunistic infections · solid organ transplant recipients

The review found no eligible studies for this question.

1 finding from 1 review

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low vs standard dose valganciclovir

Adverse events · solid organ transplant recipients

The review found no eligible studies for this question.

1 finding from 1 review

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low vs high 17ß‐oestradiol dose

Endometrial histology · young women with Turner syndrome who have completed pubertal induction

The review found no eligible studies for this question.

1 finding from 1 review

Hormone therapy for uterine and endometrial development in women with premature ovarian insufficiency 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low vs high 17ß‐oestradiol dose

Uterine perfusion · young women with Turner syndrome who have completed pubertal induction

The review found no eligible studies for this question.

1 finding from 1 review

Hormone therapy for uterine and endometrial development in women with premature ovarian insufficiency 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low vs high 17ß‐oestradiol dose

Reproductive outcomes · young women with Turner syndrome who have completed pubertal induction

The review found no eligible studies for this question.

1 finding from 1 review

Hormone therapy for uterine and endometrial development in women with premature ovarian insufficiency 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low vs high 17ß‐oestradiol dose

Adverse events · young women with Turner syndrome who have completed pubertal induction

1 finding from 1 review

Hormone therapy for uterine and endometrial development in women with premature ovarian insufficiency 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Low vs high 17ß‐oestradiol dose

Uterine volume (cm³) · young women with Turner syndrome who have completed pubertal induction

2 findings from 1 review

Hormone therapy for uterine and endometrial development in women with premature ovarian insufficiency 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low
Hormone therapy for uterine and endometrial development in women with premature ovarian insufficiency 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Low vs high 17ß‐oestradiol dose

Endometrial thickness (mm) · young women with Turner syndrome who have completed pubertal induction

The review found no eligible studies for this question.

1 finding from 1 review

Hormone therapy for uterine and endometrial development in women with premature ovarian insufficiency 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Slow vs fast subcutaneous heparin injection

Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · patients treated with subcutaneous heparin injections

1 finding from 1 review

Slow versus fast subcutaneous heparin injections for prevention of bruising and site pain intensity 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 140 participants
Low

Slow vs fast subcutaneous heparin injection

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients treated with subcutaneous heparin injections

1 finding from 1 review

Slow versus fast subcutaneous heparin injections for prevention of bruising and site pain intensity 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 103 participants
Low