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Slow may leads to lower bruise incidence ‐ 48 hours after injection compared with fast subcutaneous heparin injection (low certainty).
Low showed no clear difference in death (all causes) compared with higher dose target of rapamycin inhibitor (TOR‐I): primary outcomes (moderate certainty).
Low showed no clear difference in total graft loss (with death) compared with higher dose target of rapamycin inhibitor (TOR‐I): primary outcomes (moderate certainty).
Low probably leads to higher biopsy‐proven acute rejection compared with higher dose target of rapamycin inhibitor (TOR‐I): primary outcomes (moderate certainty).
Low showed no clear difference in CMV infection compared with higher dose target of rapamycin inhibitor (TOR‐I): primary outcomes (moderate certainty).
Low showed no clear difference in all malignancy compared with higher dose target of rapamycin inhibitor (TOR‐I): primary outcomes (moderate certainty).
Low showed no clear difference in number needing to change treatment compared with higher dose target of rapamycin inhibitor (TOR‐I): primary outcomes (low certainty).
Low probably leads to lower diabetes compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (moderate certainty).
Low showed no clear difference in lymphoma/PTLD compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (moderate certainty).
Low showed no clear difference in acne/rash compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (low certainty).
Low probably leads to lower hypercholesterolaemia compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (moderate certainty).
Low may leads to lower anaemia compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (low certainty).
Low may leads to lower thrombocytopenia compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (low certainty).
Lower lip bumper led to higher lower incisors to mandible at 6 months compared with no active treatment (control); GRADE not reported.
Lower lip bumper led to higher size of the lower jaw (mandibular arch length) at 6 months compared with no active treatment (control); GRADE not reported.
Lower lip bumper led to lower lower molars to mandible at 6 months compared with no active treatment (control); GRADE not reported.
Lower lingual arch led to higher size of the lower jaw (mandibular arch length) at 1 year compared with no active treatment (control); GRADE not reported.