Findings

What do systematic reviews say?

137 questions · 137 findings · 8 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 46 · 33.6%GRADE not reported 3 · 2.2%Very low 21 · 15.3%Low 40 · 29.2%Moderate 21 · 15.3%High 6 · 4.4%

Long‐term red cell transfusion vs usual care

Stroke · prevention of SCI in people with SCD and normal TCD velocities

Long‐term RBC transfusion showed no clear difference in clinical stroke compared with standard care (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.14 [0.02, 1.12]
1 study · 196 participants
Low

Long‐term red cell transfusion vs usual care

Cognitive function · prevention of SCI in people with SCD and normal TCD velocities

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 196 participants
Low

Long‐term red cell transfusion vs usual care

Quality of life · prevention of SCI in people with SCD and normal TCD velocities

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 196 participants
Low

Long‐term red cell transfusion vs usual care

Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and abnormal TCD velocities

Long‐term RBC transfusion may leads to lower proportion of participants developing new or progressive SCI lesions compared with standard care (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.11 [0.02, 0.86]
1 study · 124 participants
Low

Long‐term red cell transfusion vs usual care

All‐cause mortality · prevention of SCI in people with SCD and abnormal TCD velocities

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 130 participants
Very low

Hypertonic saline vs rhDNase with

FEV1 · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 47 participants
Very low

Hypertonic saline 3% to 7% vs Normal saline

FEV1 · adults and children with cystic fibrosis (stable lung disease)

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 134 participants
Low

Hypertonic saline vs amiloride

Lung function: FEV1 mL (change from baseline) · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs sodium‐2‐mercaptoethane sulphonate (Mistabron®)

FEV1 (L) · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs mannitol

FEV1 (L) · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs xylitol

FEV1 · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

FEV1 · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 3% to 7% vs Normal saline

FEV1 · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise prescription plus the use of a wearable fitness tracker vs exercise

Adherence to exercise training (long term) · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Wearable fitness tracker plus text message for personalized feedback and goal setting vs wearable fitness tracker alone

QoL · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Wearable fitness tracker plus text message for personalized feedback and goal setting vs wearable fitness tracker alone

Exercise capacity · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Web‐based application to record, monitor and set goals on physical activity plus usual care vs usual care

Adherence to exercise training (long term) · adolescents and adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Web‐based application to record, monitor and set goals on physical activity plus usual care vs usual care

Self‐management behavior (long term) · adolescents and adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Web‐based application to record, monitor and set goals on physical activity plus usual care vs usual care

QoL · adolescents and adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise prescription plus the use of a wearable fitness tracker vs exercise

Self‐management behavior (long term) · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found