Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

70 questions · 79 findings · 10 reviews · Eyes and Vision

No studies found 20 · 25.3%GRADE not reported 10 · 12.7%Very low 22 · 27.8%Low 10 · 12.7%Moderate 16 · 20.3%High 1 · 1.3%

ISBCS vs DSBCS

Complications · people with bilateral age‐related cataracts (NRSs)

It is very uncertain whether ISBCS changes complications compared with DSBCS (very low certainty).

2 findings from 1 review

ISBCS vs DSBCS

Total costs per QALY · people with bilateral age‐related cataracts (NRSs)

The review found no eligible studies for this question.

2 findings from 1 review

ISBCS vs DSBCS

BCDVA · people with bilateral age‐related cataracts (NRSs)

The review found no eligible studies for this question.

2 findings from 1 review

ISBCS vs DSBCS

Patient‐reported outcome measures (PROMs) · people with bilateral age‐related cataracts (NRSs)

The review found no eligible studies for this question.

2 findings from 1 review

ISBCS vs DSBCS

Refraction NOT within 1.0 dioptres of target · people with bilateral age‐related cataracts (NRSs)

ISBCS showed no clear difference in refraction NOT within 1.0 dioptres of target compared with DSBCS (moderate certainty).

2 findings from 1 review

Conventional occlusion vs atropine penalization

Visual acuity · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
2 findings from 1 review

Conventional occlusion vs atropine penalization

Ocular alignment (different measures and time points reported in the included studies) Assessed at different time points (17 weeks, 24 months, or cessation of treatment) and by the proportions of participants who developed strabismus, showed chang... · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Conventional occlusion vs atropine penalization

Stereo acuity (different measures and time points reported in the included studies) Assessed at different time points (17 weeks, 6 months, 2 years, or at cessation of treatment) and using different measures (TNO stereo test, Titmus fly test, Rando... · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Conventional occlusion vs atropine penalization

Quality of life (different measures and time points reported in the included studies) Assessed at different time points (17 weeks or 6 months) by patient preference or the Amblyopia Treatment Index questionnaire. · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Conventional occlusion vs atropine penalization

Adverse events (reported occurrence of: mild reduction in the visual acuity of the sound eye not requiring treatment; light sensitivity; skin, lid, or conjunctival irritation) Assessed at different time points (17 weeks or 2 years). · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Inferior oblique disinsertion vs anterior transposition

Proportion of participants who received additional strabismus surgery · people with unilateral superior oblique palsy

It is very uncertain whether inferior oblique disinsertion changes proportion of participants who received additional strabismus surgery compared with anterior transposition (very low certainty).

1 finding from 1 review