Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures
1 finding from 1 review
Seizure freedom · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intramuscular midazolam showed no clear difference in seizure cessation compared with intravenous diazepam (low certainty).
1 finding from 1 review
Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
Incidence of respiratory depression · Children with acute tonic‐clonic seizures
1 finding from 1 review
Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures
It is very uncertain whether summary of findings ‐ Intramuscular midazolam changes additional drugs required to terminate the seizure compared with intravenous diazepam (very low certainty).
1 finding from 1 review
Seizure recurrence within 24 hours: within one hour · Children with acute tonic‐clonic seizures
It is very uncertain whether summary of findings ‐ Intramuscular midazolam changes seizure recurrence within 24 hours: within one hour compared with intravenous diazepam (very low certainty).
1 finding from 1 review
Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures
1 finding from 1 review
Intervention not reported
Mortality during hospital stay · neonates requiring intubation and ventilation
The intervention showed no clear difference in mortality during hospital stay (moderate certainty).
1 finding from 1 review
Intervention not reported
Length of NICU stay (days) · neonates requiring intubation and ventilation
1 finding from 1 review
Intervention not reported
PIPP score during drug infusion Range of scale 0‐21 for infants < 28 weeks' PMA and 0‐18 for infants > 36 weeks' PMA. Lower score = less pain (Stevens 1996) · neonates requiring intubation and ventilation
The intervention showed no clear difference in PIPP score during drug infusion Range of scale 0‐21 for infants < 28… (moderate certainty).
1 finding from 1 review
Intervention not reported
Poor neurological outcome by 28 days' postnatal age · neonates requiring intubation and ventilation
The intervention showed no clear difference in poor neurological outcome by 28 days' postnatal age (moderate certainty).
1 finding from 1 review
Intervention not reported
PIPP score during drug infusion Range of scale 0‐21 for infants < 28 weeks' PMA and 0‐18 for infants > 36 weeks' PMA. Lower score = less pain (Stevens 1996) · neonates requiring intubation and ventilation
The intervention showed no clear difference in PIPP score during drug infusion Range of scale 0‐21 for infants < 28… (moderate certainty).
1 finding from 1 review
Intervention not reported
Poor neurological outcome by 28 days' postnatal age · neonates requiring intubation and ventilation
The intervention probably leads to higher poor neurological outcome by 28 days' postnatal age (moderate certainty).
1 finding from 1 review