Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

172 questions · 181 findings · 11 reviews

No studies found 35 · 19.3%GRADE not reported 3 · 1.7%Very low 68 · 37.6%Low 70 · 38.7%Moderate 5 · 2.8%High 0 · 0%

Intramuscular (IM) progesterone vs vaginal progesterone

Clinical pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether intramuscular (IM) progesterone changes clinical pregnancy rate compared with vaginal progesterone (very low certainty).

1 finding from 1 review

Progesterone vs no treatment or placebo (route of progesterone administration)

Miscarriage per clinical pregnancy · women trying to conceive by intrauterine insemination

Progesterone showed no clear difference in miscarriage per clinical pregnancy compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review

Aqueous subcutaneous (Sc) progesterone vs vaginal progesterone

Ongoing pregnancy · women trying to conceive by intrauterine insemination

It is very uncertain whether aqueous subcutaneous (Sc) progesterone changes ongoing pregnancy rate compared with vaginal progesterone gel (very low certainty).

1 finding from 1 review

Progesterone vs no treatment or placebo (route of progesterone administration)

Clinical pregnancy · women trying to conceive by intrauterine insemination

Progesterone may leads to higher clinical pregnancy per woman compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review

Aqueous subcutaneous (Sc) progesterone vs vaginal progesterone

Clinical pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether aqueous subcutaneous (Sc) progesterone changes clinical pregnancy rate compared with vaginal progesterone gel (very low certainty).

1 finding from 1 review

Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment

Ongoing pregnancy · women trying to conceive by intrauterine insemination

It is very uncertain whether subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist changes ongoing pregnancy rate compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist changes miscarriage rate compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment

Clinical pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist changes clinical pregnancy rate compared with placebo/no treatment (very low certainty).

1 finding from 1 review