What do systematic reviews say?

Combination of lidocaine intraperitoneal instillation plus intramuscular morphine vs IM morphine

Combination of lidocaine intraperitoneal instillation plus… may leads to lower number of women requiring rescue medication compared with intramuscular morphine alone (low certainty).

• Interventions for intra‐operative pain relief during postpartum mini‐laparotomy tubal ligation 2019 · Cochrane Headline outcomes only
  RR 0.11 [0.03, 0.42]
  Studies not reported
  Low

Combination of lidocaine intraperitoneal instillation plus intramuscular morphine vs placebo

• Interventions for intra‐operative pain relief during postpartum mini‐laparotomy tubal ligation 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Combination of lidocaine intraperitoneal instillation plus intramuscular morphine vs placebo

Combination of intraperitoneal lidocaine instillation and… may leads to lower number of women requiring rescue medication compared with placebo (low certainty).

• Interventions for intra‐operative pain relief during postpartum mini‐laparotomy tubal ligation 2019 · Cochrane Headline outcomes only
  RR 0.11 [0.03, 0.42]
  Studies not reported
  Low

Drainage vs no drainage after open appendectomy

It is very uncertain whether drainage changes intraperitoneal abscess compared with no drainage after open appendectomy (very low certainty).

• Abdominal drainage to prevent intra‐peritoneal abscess after appendectomy for complicated appendicitis 2021 · Cochrane Headline outcomes only
  RR 1.23 [0.47, 3.21]
  5 studies · 453 participants
  Very low

Lidocaine instillation vs placebo

• Interventions for intra‐operative pain relief during postpartum mini‐laparotomy tubal ligation 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intramuscular morphine vs placebo

• Interventions for intra‐operative pain relief during postpartum mini‐laparotomy tubal ligation 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Prosthetic mesh placement vs usual care

Prosthetic mesh placement showed no clear difference in subgroup analysis:Incidence of parastomal hernia (intraperitoneal… compared with standard treatment (moderate certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  RR 0.76 [0.55, 1.06]
  2 studies · 101 participants
  Moderate

Intervention not reported

The intervention leads to lower overall survival (high certainty).

• Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer 2016 · Cochrane Headline outcomes only
  HR 0.81 [0.72, 0.9]
  8 studies · 2026 participants
  High

Intervention not reported

The intervention leads to lower hearing loss (high certainty).

• Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer 2016 · Cochrane Headline outcomes only
  RR 0.67 [0.46, 0.99]
  3 studies · 1009 participants
  High

Intervention not reported

The intervention leads to lower progression‐free survival (high certainty).

• Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer 2016 · Cochrane Headline outcomes only
  HR 0.78 [0.7, 0.86]
  5 studies · 1311 participants
  High

Intervention not reported

The review found no eligible studies for this question.

• Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The intervention leads to higher fever (high certainty).

• Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer 2016 · Cochrane Headline outcomes only
  RR 1.64 [1.13, 2.38]
  5 studies · 1797 participants
  High

Intervention not reported

The intervention leads to higher fatigue (high certainty).

• Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer 2016 · Cochrane Headline outcomes only
  RR 2.32 [1.06, 5.07]
  3 studies · 1171 participants
  High

Intervention not reported

The intervention leads to higher gastrointestinal AEs (high certainty).

• Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer 2016 · Cochrane Headline outcomes only
  RR 1.71 [1.28, 2.26]
  5 studies · 1339 participants
  High

Intervention not reported

The intervention leads to higher infection (high certainty).

• Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer 2016 · Cochrane Headline outcomes only
  RR 3.34 [2.06, 5.43]
  3 studies · 1171 participants
  High

Intervention not reported

The intervention leads to higher metabolic AEs (high certainty).

• Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer 2016 · Cochrane Headline outcomes only
  RR 4.45 [2.72, 7.26]
  2 studies · 873 participants
  High

Intervention not reported

The intervention leads to higher pain (high certainty).

• Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer 2016 · Cochrane Headline outcomes only
  RR 7.47 [4.41, 12.67]
  3 studies · 1235 participants
  High

Intervention not reported

• Methods of intraperitoneal local anaesthetic instillation for laparoscopic cholecystectomy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 206 participants
  Very low

Intervention not reported

• Methods of intraperitoneal local anaesthetic instillation for laparoscopic cholecystectomy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 206 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes just after creation of pneumoperitoneum versus end of surgery (very low certainty).

• Methods of intraperitoneal local anaesthetic instillation for laparoscopic cholecystectomy 2014 · Cochrane Headline outcomes only
  RR 0.98 [0.65, 1.5]
  1 study · 33 participants
  Very low