Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

175 questions · 177 findings · 29 reviews

No studies found 32 · 18.1%GRADE not reported 13 · 7.3%Very low 49 · 27.7%Low 54 · 30.5%Moderate 25 · 14.1%High 4 · 2.3%

Switch to another antipsychotic vs antipsychotic cessation

Adverse effects: use of antiparkinsonism drugs · psychiatric patients (schizophrenia) with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether switch to another antipsychotic changes adverse effects: use of antiparkinsonism drugs compared with antipsychotic cessation (very low certainty).

1 finding from 1 review

Switch to another antipsychotic vs antipsychotic cessation

Leaving the study early · psychiatric patients (schizophrenia) with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether switch to another antipsychotic changes acceptability of the treatment: leaving the study early compared with antipsychotic cessation (very low certainty).

1 finding from 1 review

Switch to another antipsychotic vs antipsychotic cessation

Tardive dyskinesia: No clinically important improvement · psychiatric patients (schizophrenia) with antipsychotic‐induced tardive dyskinesia

Switch to another antipsychotic may leads to lower tardive dyskinesia: no clinically important improvement compared with antipsychotic cessation (low certainty).

1 finding from 1 review

Switching to mianserin (60 mg/d) vs continuing on current antidepressant (fluoxetine 20 mg/d)

Depressive symptoms · treatment‐resistant depression in adults

Switching to mianserin (60 mg/d) showed no clear difference in depressive symptoms (HAM‐D) Scale from: 0 to 54 (worse) compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).

1 finding from 1 review

Switching to mianserin (60 mg/d) vs continuing on current antidepressant (fluoxetine 20 mg/d)

Leaving the study early · treatment‐resistant depression in adults

Switching to mianserin (60 mg/d) showed no clear difference in dropouts compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).

1 finding from 1 review

Switching to mianserin (60 mg/d) vs continuing on current antidepressant (fluoxetine 20 mg/d)

Response (> 50% improvement on 29‐item HAM‐D SIGH‐SAD) · treatment‐resistant depression in adults

Switching to mianserin (60 mg/d) showed no clear difference in response (≥ 50% improvement in HAM‐D score) compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).

1 finding from 1 review

Switching to mianserin (60 mg/d) vs continuing on current antidepressant (fluoxetine 20 mg/d)

Remission (HAM‐D total score ≤ 8) · treatment‐resistant depression in adults

Switching to mianserin (60 mg/d) showed no clear difference in remission (HAM‐D total score ≤ 8) compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).

1 finding from 1 review