Question · asked by 1 review

Switch to another antipsychotic vs antipsychotic cessation: Leaving the study early

Population
psychiatric patients (schizophrenia) with antipsychotic‐induced tardive dyskinesia
Intervention
Switch to another antipsychotic
Comparison
antipsychotic cessation
Outcome
Leaving the study early

It is very uncertain whether switch to another antipsychotic changes acceptability of the treatment: leaving the study early compared with antipsychotic cessation (very low certainty).

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
Switch to another antipsychotic vs antipsychotic cessation
Acceptability of the treatment: leaving the study early · psychiatric patients (schizophrenia) with antipsychotic‐induced tardive dyskinesia
It is very uncertain whether switch to another antipsychotic changes acceptability of the treatment: leaving the study early compared with antipsychotic cessation (very low certainty).
Antipsychotic reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia (2018) · Cochrane Headline outcomes only
RR 0.6 [0.16, 2.25]1 study · 50 participantsVery low

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Antipsychotic reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia
2018 · Cochrane Headline outcomes only
Not reportedNot extractedNot assessed
How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.