Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

269 questions · 269 findings · 25 reviews · Hepato-Biliary

No studies found 87 · 32.3%GRADE not reported 0 · 0%Very low 117 · 43.5%Low 48 · 17.8%Moderate 14 · 5.2%High 3 · 1.1%

Recombinant human adenovirus‐p53 and hydroxycamptothecin (rAd‐p53/HCT) vs hydroxycamptothecin

Overall survival Censored · participants with unresectable hepatocellular carcinoma

It is very uncertain whether recombinant human adenovirus‐p53 and hydroxycamptothecin (rAd‐p53/HCT) changes overall survival Censored compared with hydroxycamptothecin (very low certainty).

1 finding from 1 review

Recombinant human adenovirus‐p53 and hydroxycamptothecin (rAd‐p53/HCT) vs hydroxycamptothecin

Disease progression · participants with unresectable hepatocellular carcinoma

It is very uncertain whether recombinant human adenovirus‐p53 and hydroxycamptothecin (rAd‐p53/HCT) changes proportion of people with disease progression compared with hydroxycamptothecin (very low certainty).

1 finding from 1 review

Pexastimogene devacirepvec (Pexa‐Vec) plus best supportive care vs best supportive care

Proportion of people with ≥ 1 serious adverse events (at 20 months) · participants with advanced hepatocellular carcinoma

It is very uncertain whether pexastimogene devacirepvec (Pexa‐Vec) plus best supportive care changes proportion of people with ≥ 1 serious adverse events (at 20 months) compared with best supportive care alone (very low certainty).

1 finding from 1 review

Recombinant human adenovirus‐p53 and 5‐fluorouracil (rAd‐p53/5‐Fu) plus transarterial chemoembolisation vs chemoembolisation

Disease progression · participants with unresectable hepatocellular carcinoma

It is very uncertain whether recombinant human adenovirus‐p53 and 5‐fluorouracil (rAd‐p53/5‐Fu)… changes proportion of people with disease progression compared with transarterial chemoembolisation (very low certainty).

1 finding from 1 review

E1B‐deleted (dl1520) adenovirus vs percutaneous alcohol injection

Adverse events considered non‐serious · participants with unresectable hepatocellular carcinoma

It is very uncertain whether E1B‐deleted (dl1520) adenovirus changes adverse events considered non‐serious (number of participants) compared with percutaneous ethanol injection (very low certainty).

1 finding from 1 review

Pexastimogene devacirepvec (Pexa‐Vec) plus best supportive care vs best supportive care

Disease progression · participants with advanced hepatocellular carcinoma

It is very uncertain whether pexastimogene devacirepvec (Pexa‐Vec) plus best supportive care changes proportion of people with disease progression compared with best supportive care alone (very low certainty).

1 finding from 1 review

Pexastimogene devacirepvec (Pexa‐Vec) plus best supportive care vs best supportive care

Adverse events considered non‐serious · participants with advanced hepatocellular carcinoma

It is very uncertain whether pexastimogene devacirepvec (Pexa‐Vec) plus best supportive care changes adverse events considered non‐serious (number of participants) compared with best supportive care alone (very low certainty).

1 finding from 1 review