Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

216 questions · 218 findings · 21 reviews · Heart

No studies found 30 · 13.8%GRADE not reported 1 · 0.5%Very low 49 · 22.5%Low 71 · 32.6%Moderate 48 · 22%High 19 · 8.7%

Higher vs lower omega‐6: additional key outcomes

Cardiovascular mortality · adults with or without existing CVD

It is very uncertain whether higher changes cardiovascular mortality Study duration range 24‐96 months Omega‐6… compared with lower omega‐6: primary outcomes (very low certainty).

1 finding from 1 review

Higher vs lower omega‐6: additional key outcomes

MACCEs Study duration range 24‐96 months Omega‐6 dose range 2.8%‐12.0% E · adults with or without existing CVD

It is very uncertain whether higher changes MACCEs Study duration range 24‐96 months Omega‐6 dose range… compared with lower omega‐6: primary outcomes (very low certainty).

1 finding from 1 review

Higher vs lower omega‐6: additional key outcomes

Fatal or nonfatal stroke · adults with or without existing CVD

It is very uncertain whether higher changes stroke: fatal or non‐fatal Study duration range 24‐96 months Omega‐6… compared with lower omega‐6: primary outcomes (very low certainty).

1 finding from 1 review

Higher vs lower omega‐6: additional key outcomes

MI Study duration range 12‐96 months Omega‐6 dose range 2.8%‐24.5% E · adults with or without existing CVD

Higher showed no clear difference in MI Study duration range 12‐96 months Omega‐6 dose range 2.8%‐24.5% E compared with lower omega‐6: additional key outcomes (low certainty).

1 finding from 1 review