Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,372 questions · 3,874 findings · 666 reviews

No studies found 431 · 11.1%GRADE not reported 783 · 20.2%Very low 995 · 25.7%Low 909 · 23.5%Moderate 596 · 15.4%High 160 · 4.1%

High vs low dose pegylated interferon alpha‐2a or alpha‐2b

PEG interferon (combined) · patients on HD with HCV infection

High showed no clear difference in PEG interferon (combined) compared with low dose pegylated interferon alpha‐2a or alpha‐2b (moderate certainty).

3 findings from 1 review

High vs low stimulation

50% or greater reduction in seizure frequency · people with focal seizures

High probably leads to higher 50% reduction in seizure frequency (responders) compared with low stimulation (moderate certainty).

1 finding from 1 review

High vs low stimulation

Voice Alteration or Hoarseness · people with focal seizures

High probably leads to higher voice alteration or hoarseness compared with low stimulation (moderate certainty).

1 finding from 1 review

High vs low stimulation

Paraesthesia · people with focal seizures

High showed no clear difference in paraesthesias compared with low stimulation (moderate certainty).

1 finding from 1 review