What do systematic reviews say?

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

The review found no eligible studies for this question.

• Adhesively bonded versus non‐bonded amalgam restorations for dental caries 2016 · Cochrane All outcomes
  Economic data: direct costs of materials and any reported associated indirect costs - not measured | See comment | See comment | Not estimable | - | See comment | No study addressed this outcome
  0 studies
  No studies found

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

The review found no eligible studies for this question.

• Adhesively bonded versus non‐bonded amalgam restorations for dental caries 2016 · Cochrane All outcomes
  Adverse effects: any event for which the causal relationship between the event and the amalgam restoration is at least a reasonable possibility - not measured | See comment | See comment | Not estimable | - | See…
  0 studies
  No studies found

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

The review found no eligible studies for this question.

• Adhesively bonded versus non‐bonded amalgam restorations for dental caries 2016 · Cochrane All outcomes
  Secondary caries, as diagnosed clinically - not measured | See comment | See comment | Not estimable | - | See comment | No study addressed this outcome
  0 studies
  No studies found

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

• Adhesively bonded versus non‐bonded amalgam restorations for dental caries 2016 · Cochrane All outcomes

  Baseline and 24 months
  Post‐insertion sensitivity or pain assessed by a validated pain scale - not measured | See comment | See comment | Not estimable | - | See comment | No study addressed this outcome
  1 study · 31 participants
  GRADE not reported

Resin-based fissure sealant vs Fluoride varnish

• Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of children and… 2020 · Cochrane All outcomes
  Five studies (Bravo 2005; Chestnutt 2017; Kalnina 2016; Liu 2012; Tagliaferro 2011) considered adverse events; participants detected and reported no adverse events.
  5 studies
  GRADE not reported

Highest plaque category vs Lowest plaque category

The highest plaque category was associated with higher dental caries.

• Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. 2021 All outcomes

  Highest versus lowest plaque category
  ARR 4.77 [3.67, 6.19]
  1 study · 1036 participants
  GRADE not reported

Acetone-based total-etch adhesive vs Calcium hydroxide (CH)

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  up to 24 months
  No clinical failure in any participant (Demir 2007); not estimable (direct pulp capping)
  1 study · 40 participants
  GRADE not reported

Acetone-based total-etch adhesive vs Calcium hydroxide (CH)

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  up to 24 months
  No radiological failure in any participant; not estimable
  1 study · 40 participants
  GRADE not reported

Adhesive/polyurethane sealant patch vs No treatment (both arms received flossing plus fluoride toothpaste)

Adhesive/polyurethane sealant patch showed no clear difference in caries (lesion) progression (radiographic) compared with no treatment (both arms received flossing plus fluoride toothpaste); GRADE not reported.

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  12 to 36 months (radiographic follow-up) · Sealant patch
  OR 1.00 [0.14, 7.23]
  1 study
  GRADE not reported

Highest BMI category (overweight/obese) vs Lowest BMI category (normal weight/underweight)

In the Region: Asian countries subgroup, the BMI (highest vs lowest)-childhood caries association was significant (OR 1.70, 95% CI 1.25 to 2.32; ungraded).

• Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomes

  Dental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Region: Asian countries
  OR 1.70 [1.25, 2.32]
  6 studies
  GRADE not reported
• Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomes

  Dental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Study design: cross-sectional
  OR 1.58 [1.20, 2.08]
  9 studies
  GRADE not reported
• Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomes

  Dental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Adjustment for age: yes
  OR 1.04 [0.84, 1.30]
  6 studies
  GRADE not reported

Self-etch adhesive + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes radiological failure compared with calcium hydroxide (CH) (very low certainty).

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  12 and 24 months
  RR 3.00 [0.13, 69.52]
  1 study · 40 participants
  Very low

Self-etch adhesive + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with calcium hydroxide (CH) (very low certainty).

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  6, 12 and 24 months
  RR 3.00 [0.13, 69.52]
  1 study · 40 participants
  Very low

Non-rinse conditioner + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

It is very uncertain whether non-rinse conditioner + acetone-based total-etch adhesive changes radiological failure compared with calcium hydroxide (CH) (very low certainty).

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  12 and 24 months
  RR 3.00 [0.13, 69.52]
  1 study · 40 participants
  Very low

Non-rinse conditioner + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  6 months
  No clinical failure in any participant (Demir 2007); not estimable
  1 study · 40 participants
  Very low

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with calcium hydroxide (CH) (very low certainty).

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  12 and 24 months
  RR 3.00 [0.13, 69.52]
  1 study · 40 participants
  Very low

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes radiological failure compared with calcium hydroxide (CH) (very low certainty).

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  24 months
  RR 7.00 [0.38, 127.33]
  1 study · 40 participants
  Very low

Conditioning and sealing with an adhesive resin (smear-removing bonding system) vs Conventional calcium hydroxide lining

• Pulp management for caries in adults: maintaining pulp vitality 2007 · Cochrane All outcomes

  36 months
  Whitworth 2005: 602 teeth randomised; 39 emergency recalls over the 36 months after restoration, with pulp breakdown associated with 16 teeth. The authors concluded that "dentists should be confident that pulps will be…
  1 study · 602 participants
  GRADE not reported

Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

The review found no eligible studies for this question.

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes
  None of the studies reported on participant or operator perception
  0 studies
  No studies found

Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

The review found no eligible studies for this question.

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes
  None of the studies reported on costs for micro-invasive treatment or non-invasive control
  0 studies
  No studies found

Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

Micro-invasive treatment (proximal sealing or resin infiltration):… probably leads to lower caries (lesion) progression measured by pairwise reading of… compared with non-invasive measures (e.g. fluoride varnish, flossing/oral hygiene… (moderate certainty).

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  18 to 36 months (radiographic follow-up)
  OR 0.31 [0.18, 0.53]
  4 studies
  Moderate
• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  12 to 36 months (radiographic follow-up)
  OR 0.24 [0.14, 0.41]
  7 studies · 365 participants
  Moderate
• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  12 to 18 months (radiographic follow-up)
  OR 0.18 [0.06, 0.50]
  3 studies
  Moderate