Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

77 questions · 80 findings · 9 reviews

No studies found 13 · 16.3%GRADE not reported 0 · 0%Very low 20 · 25%Low 33 · 41.3%Moderate 9 · 11.3%High 5 · 6.3%

Metformin combined with clomiphene citrate vs clomiphene

Live birth rate per woman · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate showed no clear difference in live birth rate per woman compared with clomiphene citrate alone (low certainty).

1 finding from 1 review · compare the 2 reviews

Metformin combined with clomiphene citrate vs clomiphene

Gastrointestinal adverse events · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher adverse events (gastrointestinal) per woman compared with clomiphene citrate alone (moderate certainty).

1 finding from 1 review · compare the 2 reviews

Metformin combined with clomiphene citrate vs clomiphene

Clinical pregnancy rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher clinical pregnancy rate per woman compared with clomiphene citrate alone (moderate certainty).

1 finding from 1 review · compare the 2 reviews