Depressive symptoms · adults with Major Depressive Disorder
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Acceptability ‐ total dropouts · adults with Major Depressive Disorder
Esketamine showed no clear difference in acceptability: total dropouts№ of participants: 773(5 RCTs) compared with placebo (moderate certainty).
1 finding from 1 review
OR 1.58 [0.92, 2.73]
Studies not reported
Moderate
Withdrawals due to adverse events · adults with Major Depressive Disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Remission · adults with Major Depressive Disorder
It is very uncertain whether ketamine changes efficacy: number of participants who achieve remission ‐ at 24 hours… compared with placebo (very low certainty).
1 finding from 1 review
OR 5.6 [1.07, 29.46]
Studies not reported
Very low
Depressive symptoms · adults with Major Depressive Disorder
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Acceptability ‐ total dropouts · adults with Major Depressive Disorder
It is very uncertain whether ketamine changes acceptability: total dropouts№ of participants: 201(6 RCTs) compared with placebo (very low certainty).
1 finding from 1 review
OR 1.25 [0.19, 8.28]
Studies not reported
Very low
Withdrawals due to adverse events · adults with Major Depressive Disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults with Major Depressive Disorder
It is very uncertain whether ketamine changes efficacy: number of participants who respond to treatment ‐ at 24… compared with midazolam (very low certainty).
1 finding from 1 review
OR 2.48 [1, 6.18]
Studies not reported
Very low
Remission · adults with Major Depressive Disorder
Ketamine showed no clear difference in efficacy: number of participants who achieve remission ‐ at 24 hours compared with midazolam (low certainty).
1 finding from 1 review
OR 2.21 [0.67, 7.32]
Studies not reported
Low
Depressive symptoms · adults with Major Depressive Disorder
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Acceptability ‐ total dropouts · adults with Major Depressive Disorder
Ketamine showed no clear difference in acceptability: total dropouts№ of participants: 72(1 RCT) compared with midazolam (low certainty).
1 finding from 1 review
OR 0.33 [0.05, 2.09]
Studies not reported
Low