Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

98 questions · 100 findings · 26 reviews · Headline outcomes only

No studies found 5 · 5%GRADE not reported 6 · 6%Very low 28 · 28%Low 42 · 42%Moderate 19 · 19%High 0 · 0%

Summary of findings for the main comparison. Implantable loop recorder vs conventional diagnostic workup

Aetiologic diagnosis · people with unexplained recurrent syncope

Summary of findings for the main comparison. Implantable loop recorder probably leads to lower aetiologic diagnosis compared with conventional diagnostic workup (moderate certainty).

1 finding from 1 review

Patient‐initiated appointment systems vs consultant‐led appointment systems

Cost of service utilisation · adults with a chronic or recurrent condition

It is very uncertain whether patient‐initiated appointment systems changes service utilisation (costs) per patient per year compared with consultant‐led appointment systems (very low certainty).

1 finding from 1 review

Intervention not reported

Post‐traumatic stress disorder Score Scale: Clinician Administered PTSD Scale, Posttraumatic Stress Symptoms— Interview, Posttraumatic Stress Disorder Checklist Direction: lower better · women aged 16 years and older who self‐report previous or current experience of intimate partner violence
1 finding from 1 review

Intervention not reported

Antibiotic prescriptions (number of courses/person/year) **Corticosteroids not meta‐analysed · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention may leads to higher antibiotic prescriptions (number of courses/person/year)… (low certainty).

1 finding from 1 review

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ pre‐ and postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Hostility BPRS hostility sub scale, CPRS hostility subscale, Q‐sort, speech content analysis (endpoints fall between 1 and 6 months) · Any individual experiencing recurrent aggressive outbursts or episodes
1 finding from 1 review

Intervention not reported

Anger‐Hostility POMS anger‐hostility subscale (endpoints fall between 1 and 6 months) · Any individual experiencing recurrent aggressive outbursts or episodes
1 finding from 1 review