What do systematic reviews say?

Metformin vs metformin combined with OCP

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 135 participants
  Low

Metformin vs metformin combined with OCP

Metformin showed no clear difference in adverse events ‐ Severe compared with metformin combined with oral contraceptive pill (OCP) (low certainty).

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  OR 0.74 [0.21, 2.53]
  3 studies · 171 participants
  Low

Metformin vs metformin combined with OCP

The review found no eligible studies for this question.

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs oral contraceptive pill (OCP)

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 134 participants
  Very low

Metformin vs oral contraceptive pill (OCP)

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 16 participants
  Very low

Metformin vs oral contraceptive pill (OCP)

Metformin may leads to higher adverse events ‐ Severe compared with oral contraceptive pill (OCP) (low certainty).

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  OR 6.42 [2.98, 13.84]
  11 studies · 602 participants
  Low

Metformin vs oral contraceptive pill (OCP)

The review found no eligible studies for this question.

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs oral contraceptive pill (OCP)

It is very uncertain whether metformin changes adverse event ‐ Minor compared with oral contraceptive pill (OCP) (very low certainty).

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  OR 11.67 [0.53, 258.56]
  1 study · 22 participants
  Very low

Metformin vs oral contraceptive pill (OCP)

The review found no eligible studies for this question.

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs oral contraceptive pill (OCP)

The review found no eligible studies for this question.

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs oral contraceptive pill (OCP)

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 69 participants
  Very low

Metformin vs oral contraceptive pill (OCP)

The review found no eligible studies for this question.

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs oral contraceptive pill (OCP)

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 153 participants
  Low

Metformin vs oral contraceptive pill (OCP)

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  Low

Metformin vs oral contraceptive pill (OCP)

• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 451 participants
  Very low