Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

395 questions · 404 findings · 37 reviews · Headline outcomes only

No studies found 83 · 20.5%GRADE not reported 41 · 10.1%Very low 127 · 31.4%Low 115 · 28.5%Moderate 38 · 9.4%High 0 · 0%

Cognitive behaviour therapy + treatment‐as‐usual vs usual care

Physical aggression · adults with antisocial personality disorder

Cognitive behaviour therapy + treatment‐as‐usual showed no clear difference in aggression (any act of physical aggression) Assessed by: number… compared with treatment‐as‐usual alone (low certainty).

1 finding from 1 review

Cognitive behaviour therapy vs treatment

Parasuicidality ‐ CBT vs. TAUno. of participants with self‐harming behaviour (last 12 months) · patients with borderline personality disorder

Cognitive‐Behavioural Therapy (CBT) showed no clear difference in parasuicidality ‐ CBT vs. TAUno. of participants with self‐harming… compared with treatment (moderate certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy + risperidone vs placebo and cognitive and behavioural therapies

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Endpoint data (events) compared with cognitive behavioural therapy + placebo (very low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy + risperidone vs placebo and cognitive and behavioural therapies

Adverse effects: specific ‐ doctors' assessment of adverse effects UKU (events) Medium‐term · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes adverse effects: specific ‐ doctors' assessment of adverse effects… compared with cognitive behavioural therapy + placebo (very low certainty).

1 finding from 1 review