Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

96 questions · 109 findings · 14 reviews

No studies found 11 · 10.1%GRADE not reported 3 · 2.8%Very low 21 · 19.3%Low 52 · 47.7%Moderate 22 · 20.2%High 0 · 0%

Exposure to clomiphene citrate and gonadotropins for subfertility vs general population and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to clomiphene citrate and gonadotropins for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).

1 finding from 1 review

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple (all cycles)‐ clomiphene citrate or letrozole · participants with unexplained subfertility

IUI in a stimulated cycle probably leads to higher live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

1 finding from 1 review

Antioestrogen vs antioestrogen

Clinical pregnancy rate · ovulation induction in polycystic ovarian syndrome

It is very uncertain whether antioestrogen changes clomiphene citrate plus tamoxifen versus clomiphene citrate ‐… compared with antioestrogen (very low certainty).

2 findings from 1 review

Antioestrogen plus medical adjunct vs antioestrogen

Clinical pregnancy · ovulation induction in polycystic ovarian syndrome

Antioestrogen plus medical adjunct showed no clear difference in clomiphene citrate plus bromocriptine versus clomiphene citrate ‐… compared with antioestrogen alone (low certainty).

1 finding from 1 review

Intervention not reported

Live birth ‐ Clomiphene citrate 5 days versus clomiphene citrate 10 days · ovulation induction in polycystic ovarian syndrome

The intervention may leads to lower live birth ‐ Clomiphene citrate 5 days versus clomiphene citrate 10… (low certainty).

1 finding from 1 review

Intervention not reported

Clinical pregnancy ‐ Clomiphene citrate 5 days versus clomiphene citrate 10 days · ovulation induction in polycystic ovarian syndrome

The intervention may leads to lower clinical pregnancy ‐ Clomiphene citrate 5 days versus clomiphene… (low certainty).

1 finding from 1 review

Intervention not reported

Multiple pregnancy ‐ Clomiphene citrate 5 days versus clomiphene citrate 10 days · ovulation induction in polycystic ovarian syndrome

It is very uncertain whether the intervention changes multiple pregnancy ‐ Clomiphene citrate 5 days versus clomiphene… (very low certainty).

1 finding from 1 review

Intervention not reported

Miscarriage rate ‐ Early versus late clomiphene citrate · ovulation induction in polycystic ovarian syndrome

It is very uncertain whether the intervention changes miscarriage rate ‐ Early versus late clomiphene citrate (very low certainty).

1 finding from 1 review

Intervention not reported

Clinical pregnancy ‐ Early versus late clomiphene citrate · ovulation induction in polycystic ovarian syndrome

The intervention may leads to higher clinical pregnancy ‐ Early versus late clomiphene citrate (low certainty).

1 finding from 1 review