Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

91 questions · 105 findings · 18 reviews

No studies found 15 · 14.3%GRADE not reported 53 · 50.5%Very low 23 · 21.9%Low 9 · 8.6%Moderate 5 · 4.8%High 0 · 0%

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less
2 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs No fluoride supplement (placebo or no treatment)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less
3 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Plaque and gingivitis scores · Children and adolescents aged 16 years or less
1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs No fluoride supplement (placebo or no treatment)

Fluorosis (adverse effect; % of children with fluorotic teeth, questionable to severe) · Children and adolescents aged 16 years or less
1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Filled primary surfaces at 3 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

Fluoride supplementation (tablets, drops, lozenges or chewing gum) showed no clear difference in filled primary surfaces at 5 years compared with placebo or no treatment; GRADE not reported.

2 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Caries presence in primary teeth · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes children with caries in the primary teeth at 3 years compared with placebo or no treatment (very low certainty).

2 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Fluorosis (maxillary teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes fluorosis (maxillary teeth) at 5 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Caries in primary teeth: dmft (3 years) · Pregnant women (for preventing dental caries in the primary teeth of their children)

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Fluorosis (mandibular teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes fluorosis (mandibular teeth) at 5 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Decayed primary surfaces at 3 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

Fluoride supplementation (tablets, drops, lozenges or chewing gum) showed no clear difference in decayed primary surfaces at 3 years compared with placebo or no treatment; GRADE not reported.

2 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Decayed or filled primary tooth surfaces at 3 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes decayed or filled primary tooth surfaces at 3 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Decayed or filled primary tooth surfaces at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes decayed or filled primary tooth surfaces at 5 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Consumption of xylitol chewing gum by women (mothers) vs Consumption of CHX/xylitol gum by women, or CHX varnish applied to women's dentition

Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age

It is very uncertain whether consumption of xylitol chewing gum by women (mothers) changes caries presence in primary teeth compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to… (very low certainty).

1 finding from 1 review