Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

109 questions · 152 findings · 8 reviews · Developmental, Psychosocial and Learning Problems

No studies found 42 · 27.6%GRADE not reported 7 · 4.6%Very low 33 · 21.7%Low 38 · 25%Moderate 31 · 20.4%High 1 · 0.7%

Summary of findings: Trihexyphenidyl vs placebo

Adverse effectsb (mood disturbance, irritability, behavioural change, constipation) Measured by: counts of number and type · children with dystonic cerebral palsy

Summary of findings: Trihexyphenidyl may leads to higher adverse effectsb (mood disturbance, irritability, behavioural… compared with placebo (low certainty).

1 finding from 1 review

Summary of findings: Trihexyphenidyl vs placebo

Participation in activities of daily living:individual goal setting Measured by: GAS (up to 5 functional goals scored on a 5‐point scale (−2 = much less than expected to +2 = much more than expected); higher score = better than expected outcome) · children with dystonic cerebral palsy
1 finding from 1 review

Summary of findings: Trihexyphenidyl vs placebo

Participation in activities of daily living:satisfaction with individual goals Measured by: satisfaction subscale of the COPM (satisfaction with performance in up to 5 problem areas scored on a 10‐point scale (1 = not satisfied at all to 10 = extr... · children with dystonic cerebral palsy
1 finding from 1 review

Summary of findings: Trihexyphenidyl vs placebo

Participation in activities of daily living:performance of individual goals Measured by: performance subscale of the COPM (up to five problem areas scored on a 10‐point scale (1 = not able to do to 10 = able to do extremely well; higher score = be... · children with dystonic cerebral palsy
1 finding from 1 review