Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

119 questions · 121 findings · 22 reviews · Headline outcomes only

No studies found 12 · 9.9%GRADE not reported 7 · 5.8%Very low 36 · 29.8%Low 43 · 35.5%Moderate 19 · 15.7%High 4 · 3.3%

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Mother to Child Transmission at Birth · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora continued: AZT/3TC/LPV‐r showed no clear difference in mother to Child Transmission at Birth compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Mother to Child Transmission at 6 Weeks · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora continued: AZT/3TC/LPV‐r showed no clear difference in mother to Child Transmission at 6 Weeks compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Mother to Child Transmission at 6 Months · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora continued: AZT/3TC/LPV‐r may leads to lower mother to Child Transmission at 6 Months compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Mother to Child Transmission at 12 Months · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

It is very uncertain whether kesho Bora continued: AZT/3TC/LPV‐r changes mother to Child Transmission at 12 Months compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (very low certainty).

1 finding from 1 review

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Women With Any Grade 3/4 Severe Adverse Event (Laboratory Only) · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

It is very uncertain whether mma Bana: AZT/3TC/LPV‐r changes women With Any Grade 3/4 Severe Adverse Event (Laboratory Only) compared with AZT/3TC/ABC (very low certainty).

1 finding from 1 review

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Women With Any Severe Adverse Events Requiring Treatment Modification · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

It is very uncertain whether mma Bana: AZT/3TC/LPV‐r changes women With Any Severe Adverse Events Requiring Treatment Modification compared with AZT/3TC/ABC (very low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV Transmission or Death at 12 Months · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

It is very uncertain whether kesho Bora: AZT/3TC/LPV‐r changes infant HIV Transmission or Death at 12 months compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (very low certainty).

1 finding from 1 review

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Mother to Child Transmission In Utero Positive HIV DNA PCR Within 96 Hours · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

Mma Bana continued: AZT/3TC/LPV‐r showed no clear difference in mother to Child Transmission In Utero Positive HIV DNA PCR Within 96… compared with AZT/3TC/ABC (low certainty).

1 finding from 1 review

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Mother to Child Transmission Late Postpartum Negative HIV DNA PCR at Birth and One Month, But Positive HIV DNA PCR at Six Months · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

Mma Bana continued: AZT/3TC/LPV‐r showed no clear difference in mother to Child Transmission Late Postpartum Negative HIV DNA PCR at… compared with AZT/3TC/ABC (low certainty).

1 finding from 1 review

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Mother to Child Transmission at 6 Weeks · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

Mma Bana continued: AZT/3TC/LPV‐r showed no clear difference in mother to Child Transmission at Six Months Post‐Partum All Positive… compared with AZT/3TC/ABC (low certainty).

1 finding from 1 review

Bae: AZT/3TC/NVP vs AZT (+/‐ single dose NVP)

HIV‐Transmission or Death at 7 Months · HIV‐infected pregnant women with CD4 Counts <200 cells/mm31

It is very uncertain whether bae: AZT/3TC/NVP changes HIV‐Transmission or Death at 7 Months compared with AZT (+/‐ single dose NVP) (very low certainty).

1 finding from 1 review

Bae: AZT/3TC/NVP vs AZT (+/‐ single dose NVP)

Infant Grade 3/4 Severe Adverse Events at Birth · HIV‐infected pregnant women with CD4 Counts <200 cells/mm31

It is very uncertain whether bae: AZT/3TC/NVP changes infant Grade 3/4 Severe Adverse Events at Birth compared with AZT (+/‐ single dose NVP) (very low certainty).

1 finding from 1 review