Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

102 questions · 102 findings · 13 reviews

No studies found 15 · 14.7%GRADE not reported 4 · 3.9%Very low 14 · 13.7%Low 34 · 33.3%Moderate 34 · 33.3%High 1 · 1%

First‐line thiazides vs calcium channel blockers

Adverse effects (side effects; treatment withdrawals) · patients with hypertension

First‐line thiazides may leads to lower withdrawals due to adverse effects Duration: 1 to 5 years compared with first‐line calcium channel blockers (low certainty).

1 finding from 1 review

First‐line thiazides vs calcium channel blockers

Total serious adverse events Duration: 1.75 to 3 years · patients with hypertension

First‐line thiazides showed no clear difference in total serious adverse events Duration: 1.75 to 3 years compared with first‐line calcium channel blockers (low certainty).

1 finding from 1 review