Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

106 questions · 113 findings · 11 reviews

No studies found 21 · 18.6%GRADE not reported 29 · 25.7%Very low 29 · 25.7%Low 18 · 15.9%Moderate 15 · 13.3%High 1 · 0.9%

CLOZAPINE + RISPERIDONE vs PLACEBO + CLOZAPINE

Mental state: No 20% response (as defined by PANSS/BPRS total change) · patients with schizophrenia

RISPERIDONE + CLOZAPINE showed no clear difference in mental state: no clinically significant response in psychotic… compared with PLACEBO + CLOZAPINE (low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs PLACEBO + CLOZAPINE

Global state: 2. no significant clinical improvement ‐ CGI, short term (up to 12 weeks) · patients with schizophrenia

RISPERIDONE + CLOZAPINE showed no clear difference in global state: no significant clinical improvement ‐ CGI short term compared with PLACEBO + CLOZAPINE (low certainty).

1 finding from 1 review